Document Detail

Serum transferrin receptor assays and their application.
MedLine Citation:
PMID:  12038596     Owner:  NLM     Status:  MEDLINE    
Most cells acquire iron from plasma transferrin and it is the transferrin receptor that is responsible for the internalization of transferrin-bound iron and its subsequent intracellular release. Plasma concentrations of the receptor reflect cellular receptor numbers and may be determined by enzyme immunoassay on automated analysers. Although determination of receptor concentrations may provide little additional value to existing measures of iron status, particular circumstances may dictate the use of these assays. This review summarizes transferrin receptor physiology and biochemistry, the limitations of the methodology that is currently available and the clinical application of assays (a) in monitoring changes in the rate of erythropoiesis, (b) as an indicator of developing iron deficiency and (c) in identifying iron deficiency in patients with anaemia of chronic disease.
Mark Worwood
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  39     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-31     Completed Date:  2003-01-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  221-30     Citation Subset:  IM    
Department of Haematology, University of Wales College of Medicine, Cardiff, UK.
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MeSH Terms
Anemia, Iron-Deficiency / blood,  diagnosis,  metabolism
Immunoenzyme Techniques
Iron / metabolism
Iron Overload / blood,  metabolism
Receptors, Transferrin / analysis*,  metabolism
Reference Values
Sensitivity and Specificity
Reg. No./Substance:
0/Receptors, Transferrin; 7439-89-6/Iron

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