Document Detail

Serum total testosterone levels in a patient with late onset 21-hydroxylase deficiency and a twin gestation.
MedLine Citation:
PMID:  17418835     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To present serum androgen levels during pregnancy in a twin gestation complicated by maternal late onset 21-hydroxylase deficiency. DESIGN: Case report. SETTING: University teaching hospital reproductive endocrinology and infertility practice. PATIENT(S): A 27-year-old with nonclassic 21-hydroxylase deficiency and infertility, twin female fetuses, and elevated androgens. INTERVENTION(S): Steroid replacement. MAIN OUTCOME MEASURE(S): Serum T and 17-hydroxyprogesterone (17-OHP) levels. RESULT(S): Elevated androgen levels persisted throughout pregnancy in spite of aggressive steroid replacement. However, twin girls were born without any evidence of virilization. CONCLUSION(S): The changes associated with a twin gestation may result in excessive stimulation of androgens in mothers with nonclassic 21-hydroxylase deficiency. However, the increased placental aromatase provides protection.
Lindsay M Mains; Ruth B Lathi; Richard O Burney; Michael H Dahan
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-04-06
Journal Detail:
Title:  Fertility and sterility     Volume:  87     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-04     Completed Date:  2007-05-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1212.e5-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Ochsner Clinic Foundation, New Orleans, Louisiana, USA.
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MeSH Terms
Adrenal Hyperplasia, Congenital / blood*,  enzymology,  genetics
Pregnancy, Multiple / blood*,  genetics
Steroid 21-Hydroxylase / blood*,  genetics
Testosterone / blood*
Twins / blood*,  genetics
Reg. No./Substance:
58-22-0/Testosterone; EC 21-Hydroxylase

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