| Serum total bile acid levels in patients receiving rifampicin and isoniazid. | |
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MedLine Citation:
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PMID: 6476775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum bile acid levels in 61 patients receiving daily doses of rifampicin and isoniazid for the treatment of tuberculosis have been investigated. Bile acids were measured using 3 alpha-hydroxysteroid dehydrogenase in a continuous-flow system. Abnormally elevated levels were found in 44 patients (72%) during the period of study up to 80 days after onset of treatment. The results showed a mean of 24.9 mumol/l and a positively skewed distribution. Whilst marginally raised levels of bilirubin were seen in some samples (mean 8.2 mumol/l), these did not reflect the marked changes observed in bile acids. Patients receiving rifampicin and isoniazid may therefore have markedly elevated levels of total serum bile acids, while other tests used to assess liver function can remain normal. |
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Authors:
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J D Berg; H I Pandov; H G Sammons |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of clinical biochemistry Volume: 21 ( Pt 3) ISSN: 0004-5632 ISO Abbreviation: Ann. Clin. Biochem. Publication Date: 1984 May |
Date Detail:
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Created Date: 1984-09-25 Completed Date: 1984-09-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0324055 Medline TA: Ann Clin Biochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 218-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Bile Acids and Salts / blood* Drug Therapy, Combination Female Humans Isoniazid / adverse effects*, therapeutic use Male Middle Aged Rifampin / adverse effects*, therapeutic use Tuberculosis, Pulmonary / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 13292-46-1/Rifampin; 54-85-3/Isoniazid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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