| Serum and tissue CTACK/CCL27 chemokine levels in early mycosis fungoides and disease control by ifn-a and puva therapy. | |
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MedLine Citation:
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PMID: 22233400 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Neoplastic T cells recruitment into the skin is a critical step in mycosis fungoides (MF) pathogenesis and the cutaneous T-cell attracting chemokine CTACK/CCL27 might be involved. Objectives: Aim of our study was to investigate the clinical and prognostic significance of CTACK/CCL27 levels in patients with early stage MF. Methods: Serum samples and skin biopsy specimens were collected from 15 patients at the time of the diagnosis, and after the end of treatment with PUVA/IFNα2b combination therapy. Serum samples were also collected from 20 healthy donors as controls. CTACK/CCL27 serum levels were analyzed by ELISA assays. CTACK/CCL27 tissue expression was determined by immunohistochemistry on skin biopsy specimens taken at diagnosis and after therapy. Event-free survival was taken as primary clinical outcome. All statistical analyses were performed using the SPSS statistical package. Results: In MF patients at diagnosis CTACK/CCL27 serum levels were not significantly different from healthy controls, whereas CTACK/CCL27 expression in skin was increased in 87% of cases compared to normal controls. After therapy all patients obtained a clinical complete remission, serum levels did not change significantly and tissue expression remained abnormal in 80% of patients, even if a complete histological remission was recorded. Serum levels were not significantly different in cases with different intensity of cutaneous immunostaining. Eight patients experienced a relapse: the combination of high CTACK/CCL27 levels both in sera and in skin increased the probability to experience an event at 51 months from 36% to 83%. Conclusions: Our data seem to indicate that CTACK/CCL27 levels in skin and sera after therapy might be correlated with risk of recurrence. |
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Authors:
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G Goteri; S Rupoli; A Campanati; A Zizzi; P Picardi; M Cardelli; F Giantomassi; L Canafoglia; F Marchegiani; G Mozzicafreddo; G Brandozzi; D Stramazzotti; G Ganzetti; R Lisa; O Simonetti; A Offidani; I Federici; G Filosa; P Leoni |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-11 |
Journal Detail:
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Title: The British journal of dermatology Volume: - ISSN: 1365-2133 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 British Association of Dermatologists. |
Affiliation:
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Anatomic Pathology Clinic of Hematology Dermatological Clinic, Ancona Hospital, Polytechnic Marche University Advanced Technology Center for Aging Research, Scientific Technological Area and Scientific Direction Division of Dermatology, I.N.R.C.A- I.R.C.C.S., Ancona Division of Dermatology, Murri Hospital, Jesi, Italy. |
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