| Serum thyroglobulin and iodine-131 whole-body scan in the diagnosis and assessment of treatment for metastatic differentiated thyroid carcinoma. | |
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MedLine Citation:
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PMID: 8294995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Because of the limitations of periodic 131I whole-body scans, including suspension of substitution therapy, questionable sensitivity and low yield in detecting metastases in patients who have undergone thyroidectomy, serum thyroglobulin and 131I whole-body scans were evaluated for sensitivity in detecting local, regional or distant metastases in 261 patients with differentiated thyroid carcinoma after total thyroidectomy and ablation. METHODS: A noncompetitive immunoradiometric assay was used for serum thyroglobulin determination. An 131I whole-body scan was obtained after replacement therapy had been suspended for 6 wk or when TSH reached levels higher than 50 microU/ml. In patients who underwent radiological procedures with iodinated contrast media, the waiting period before the 131I whole-body scan was no less than 10 wk. RESULTS: Of the 58 patients with proven metastases who were followed for 12 yr (mean 7 +/- 3.3 yr), 51 (88.4%) had high serum thyroglobulin assays performed while under full replacement therapy and 32 (55%) showed clear 131I whole-body scan localization. There were no instances of positive whole-body scans and negative serum thyroglobulin. CONCLUSION: In patients treated with 131I, serum thyroglobulin assay was an excellent method to assess treatment. Patients with metastatic disease and negative whole-body scans with or without serum thyroglobulin exhibited a trend toward higher mortality. This trend may also indicate that the lack of 131I trapping and low thyroglobulin is a sign of metabolic dedifferentiation of otherwise histologically differentiated thyroid tumors. |
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Authors:
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E Lubin; S Mechlis-Frish; S Zatz; A Shimoni; K Segal; A Avraham; R Levy; R Feinmesser |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 35 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1994 Feb |
Date Detail:
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Created Date: 1994-03-02 Completed Date: 1994-03-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 257-62 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Beilinson Medical Center, Petah Tiqva, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma, Follicular
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pathology,
radionuclide imaging,
surgery Adult Aged Carcinoma, Papillary / pathology, radionuclide imaging, surgery Female Follow-Up Studies Humans Iodine Radioisotopes / diagnostic use*, therapeutic use Male Middle Aged Neoplasm Metastasis Thyroglobulin / blood* Thyroid Neoplasms / pathology*, radionuclide imaging, surgery Thyroidectomy |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes; 9010-34-8/Thyroglobulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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