Document Detail


Serum thymidine kinase and beta-2 microglobulin in monoclonal gammopathies.
MedLine Citation:
PMID:  3318049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the serum thymidine kinase (TK) and beta-2 microglobulin (beta-2) levels of 22 patients with monoclonal gammopathy of undetermined significance (MGUS) and of 29 patients with multiple myeloma (MM). Both parameters were significantly lower in MGUS than in MM patients and in early (stage I + II) than in advanced (stage III) MM. TK was also lower in MGUS than in stage I MM (p less than 0.025). A seven-fold increase of TK level was documented in one patient who developed a full blown picture of MM 6 years after a diagnosis of MGUS. In 3 patients with stage III MM, a sharp decrease in TK (40-77%) and in beta-2 (29-53%) levels at remission was evident with respect to the levels measured at diagnosis. Patients with high levels of TK or beta-2 had a shorter survival than those with low levels; however, this was statistically significant only for beta-2 levels (p less than 0.02). Serum TK as well as beta-2 levels appear to be of clinical value in monoclonal gammopathies and related to the course of the disease.
Authors:
G Ucci; A Riccardi; R Luoni; P Spriano; G Merlini; M Danova; E Cassano; E Molinari; E Ascari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tumori     Volume:  73     ISSN:  0300-8916     ISO Abbreviation:  Tumori     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-12-30     Completed Date:  1987-12-30     Revised Date:  2008-12-12    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  445-9     Citation Subset:  IM    
Affiliation:
Istituto di Clinica Medica II, Università di Pavia, Italia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Humans
Male
Middle Aged
Multiple Myeloma / blood,  mortality
Paraproteinemias / blood*
Prognosis
Retrospective Studies
Thymidine Kinase / blood*
beta 2-Microglobulin / metabolism*
Chemical
Reg. No./Substance:
0/beta 2-Microglobulin; EC 2.7.1.21/Thymidine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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