Document Detail


Serum testosterone and short-term mortality in men with acute myocardial infarction.
MedLine Citation:
PMID:  20535714     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A significant and independent association between testosterone levels and coronary events in men and women has not been confirmed in large prospective studies, although some reports have shown that endogenous testosterone concentrations in men are inversely related to cardiovascular and general mortality. METHODS: We aimed to assess the relationship between serum testosterone level and short-time (30-day) mortality in men with acute myocardial infarction. RESULTS: We included 126 consecutive male patients admitted with acute myocardial infarction. The mean age was 62 +/- 13 years. We determined, at admission, serum free testosterone (T) level (using a chemoluminiscence assay), high sensitivity C-reactive protein, N-terminal pro-B-type natriuretic peptide, and glycated hemoglobin level. We analyzed the 30-day mortality. CONCLUSIONS: The mean level of serum T was 4.1 +/- 2.9 ng/mL. All non-survivors had T level < or = 3 ng/mL. A low level of T was independently related to total short-term mortality.
Authors:
Constantin Militaru; Ionut Donoiu; Ovidiu Dracea; Dan-Dominic Ionescu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology journal     Volume:  17     ISSN:  1897-5593     ISO Abbreviation:  Cardiol J     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  249-53     Citation Subset:  IM    
Affiliation:
Craiova Cardiology Center, Romania.
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MeSH Terms
Descriptor/Qualifier:
Aged
Biological Markers / blood
C-Reactive Protein / analysis
Chi-Square Distribution
Down-Regulation
Hemoglobin A, Glycosylated / analysis
Humans
Logistic Models
Male
Middle Aged
Myocardial Infarction / blood*,  mortality*
Natriuretic Peptide, Brain / blood
Odds Ratio
Patient Admission
Peptide Fragments / blood
Prognosis
Risk Assessment
Risk Factors
Romania / epidemiology
Survival Analysis
Testosterone / blood*
Time Factors
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Hemoglobin A, Glycosylated; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; 58-22-0/Testosterone; 9007-41-4/C-Reactive Protein
Comments/Corrections
Comment In:
Cardiol J. 2010;17(3):217-8   [PMID:  20535710 ]

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