| Serum surfactant protein-A levels in patients with acute cardiogenic pulmonary edema and adult respiratory distress syndrome. | |
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MedLine Citation:
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PMID: 7599839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Detection of alveolo-capillary damage has important implications for treatment modalities in ventilated patients. Although surfactant protein-A (SP-A) is normally only found in appreciable amounts in the lung, we describe significantly elevated concentrations in the sera of patients with acute cardiogenic pulmonary edema (median, 250 ng/ml; range, 180 to 364; n = 10) and in those with the adult respiratory distress syndrome (ARDS) (median, 378 ng/ml; range, 215 to 1,378; n = 15) relative to healthy control subjects (median, 175 ng/ml; range, 123 to 248; n = 15) and ventilated patients with no cardiorespiratory disease (median, 169 ng/ml; range, 126 to 253; n = 6) (p < 0.01, in all cases). Serum SP-A was inversely related to blood oxygenation and to static respiratory system compliance both at the time of the patient's entry into the study (p < 0.005, rs = -0.51, n = 31; p < 0.001, rs = 0.82, n = 17; respectively) and during the course of admission (p < 0.001, rs = -0.34, n = 168; p < 0.001, rs = -0.50, n = 111; respectively). In addition, we describe in detail three cases of ARDS where lung function either improved, remained static, or deteriorated. We conclude that serum SP-A is an acute indicator of lung function and alveolo-capillary membrane injury. |
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Authors:
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I R Doyle; T E Nicholas; A D Bersten |
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Publication Detail:
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Type: Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 152 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1995-08-10 Completed Date: 1995-08-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 307-17 Citation Subset: AIM; IM |
Affiliation:
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Department of Human Physiology, School of Medicine, Flinders Medical Centre, Adelaide, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood-Air Barrier / physiology* Case-Control Studies Enzyme-Linked Immunosorbent Assay Female Glycoproteins / blood* Humans Lung Compliance / physiology Male Middle Aged Overdose / blood, therapy Oxygen / blood Proteolipids / blood* Pulmonary Edema / blood*, physiopathology, therapy Pulmonary Surfactant-Associated Protein A Pulmonary Surfactant-Associated Proteins Pulmonary Surfactants / blood* Respiration, Artificial Respiratory Distress Syndrome, Adult / blood*, physiopathology, therapy |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Proteolipids; 0/Pulmonary Surfactant-Associated Protein A; 0/Pulmonary Surfactant-Associated Proteins; 0/Pulmonary Surfactants; 7782-44-7/Oxygen |
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