Document Detail

Serum-surfactant SP-D correlates inversely to lung function in cystic fibrosis.
MedLine Citation:
PMID:  20457545     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cystic fibrosis (CF) affects the lungs causing infections and inflammation. Surfactant protein D (SP-D) is an innate defense lectin primarily secreted in the lungs. We investigated the influence of the SP-D Met11Thr polymorphism on CF lung function; and serum SP-D as a marker for CF lung disease. METHODS: For 107 CF patients (73 children, and 34 adults) serum SP-D and SP-D Met11Thr genotype were available. Leukocyte count was obtained for a subset of patients. Lung function was measured as forced expiratory volume in one second (FEV-1). RESULTS: Serum SP-D was increased in CF patients compared to healthy controls, positively correlated to leukocyte count, and negatively correlated to FEV-1. We found no correlation between SP-D Met11Thr genotype and FEV-1, and we found corresponding genotype frequencies in CF patients and in healthy controls. CONCLUSION: Serum SP-D in CF patients was increased in parallel with leukocyte count and with reduced FEV-1 and may constitute an alternative biomarker for lung disease, in the clinical setting and in research.
Hanne Vebert Olesen; Uffe Holmskov; Peter Oluf Schiøtz; Grith Lykke Sørensen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-08
Journal Detail:
Title:  Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society     Volume:  9     ISSN:  1873-5010     ISO Abbreviation:  J. Cyst. Fibros.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128966     Medline TA:  J Cyst Fibros     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  257-62     Citation Subset:  IM    
Copyright Information:
Copyright 2010 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
Department of Pediatrics, Aarhus University Hospital, Skejby, 8200 Arhus N, Denmark.
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MeSH Terms
Biological Markers / blood
Case-Control Studies
Cystic Fibrosis / blood*,  physiopathology*
Forced Expiratory Volume
Leukocyte Count
Middle Aged
Polymorphism, Single Nucleotide
Pulmonary Surfactant-Associated Protein D / blood*,  genetics
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Pulmonary Surfactant-Associated Protein D

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