| Serum-surfactant SP-D correlates inversely to lung function in cystic fibrosis. | |
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MedLine Citation:
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PMID: 20457545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cystic fibrosis (CF) affects the lungs causing infections and inflammation. Surfactant protein D (SP-D) is an innate defense lectin primarily secreted in the lungs. We investigated the influence of the SP-D Met11Thr polymorphism on CF lung function; and serum SP-D as a marker for CF lung disease. METHODS: For 107 CF patients (73 children, and 34 adults) serum SP-D and SP-D Met11Thr genotype were available. Leukocyte count was obtained for a subset of patients. Lung function was measured as forced expiratory volume in one second (FEV-1). RESULTS: Serum SP-D was increased in CF patients compared to healthy controls, positively correlated to leukocyte count, and negatively correlated to FEV-1. We found no correlation between SP-D Met11Thr genotype and FEV-1, and we found corresponding genotype frequencies in CF patients and in healthy controls. CONCLUSION: Serum SP-D in CF patients was increased in parallel with leukocyte count and with reduced FEV-1 and may constitute an alternative biomarker for lung disease, in the clinical setting and in research. |
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Authors:
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Hanne Vebert Olesen; Uffe Holmskov; Peter Oluf Schiøtz; Grith Lykke Sørensen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-08 |
Journal Detail:
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Title: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society Volume: 9 ISSN: 1873-5010 ISO Abbreviation: J. Cyst. Fibros. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-10-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128966 Medline TA: J Cyst Fibros Country: Netherlands |
Other Details:
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Languages: eng Pagination: 257-62 Citation Subset: IM |
Copyright Information:
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Copyright 2010 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Pediatrics, Aarhus University Hospital, Skejby, 8200 Arhus N, Denmark. hvo@dadlnet.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Biological Markers / blood Case-Control Studies Child Cystic Fibrosis / blood*, physiopathology* Female Forced Expiratory Volume Humans Leukocyte Count Male Middle Aged Polymorphism, Single Nucleotide Pulmonary Surfactant-Associated Protein D / blood*, genetics Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Pulmonary Surfactant-Associated Protein D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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