| Serum sperm antibodies after diarrhoeal diseases. | |
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MedLine Citation:
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PMID: 17683470 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The origin of 'natural' anti-sperm antibodies found in fertile humans, virgin girls, and boys before puberty, is quite obscure. One hypothetical mechanism relates their existence to inflammatory gastrointestinal entities: as a result of the disease, cross-reactive antibodies produced against gastrointestinal flora bind spermatozoa. To test this assumption, we evaluated the level of serum sperm antibodies after diarrhoeal infections. Serum samples from 17 patients with shigellosis and 12 patients with salmonellosis were screened for anti-sperm antibodies directed against sperm surface antigens (gelatin agglutination test - GAT, tray agglutination test - TAT, sperm immobilization test - SIT), profound sperm antigens [enzyme-linked immunosorbent assay (ELISA)], and anti-bacterial antibodies (slide agglutination test - SAT) upon diagnosis (group A) and 4-35 days later (group B). The patients from group B demonstrated an increased sperm antibody incidence by GAT (20.7%), TAT (13.8%) and ELISA (31%) when compared to group A and to healthy controls, although statistically significant data were acquired only for the latter group. The absorption of positive sera with bacteria and/or spermatozoa revealed significant reactivity changes in the antibody values by GAT and TAT for shigellosis, and by TAT and ELISA for salmonellosis patients. These data demonstrate increased serum sperm antibody levels in salmonellosis and shigellosis patients. |
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Authors:
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S Kalaydjiev; D Dimitrova; I Mitov; I Dikov; L Nakov |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Andrologia Volume: 39 ISSN: 0303-4569 ISO Abbreviation: Andrologia Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-08-08 Completed Date: 2007-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0423506 Medline TA: Andrologia Country: Germany |
Other Details:
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Languages: eng Pagination: 101-8 Citation Subset: IM |
Affiliation:
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Department of Biology, Medical University of Sofia, Sofia, Bulgaria, and Faculty of Life Sciences, University of Manchester, Manchester, UK. svetoslav.kalaydjiev@manchester.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antibodies / analysis* Antibodies, Bacterial / analysis Dysentery / immunology* Dysentery, Bacillary / immunology Female Humans Male Middle Aged Salmonella / immunology Salmonella Infections / immunology Shigella / immunology Spermatozoa / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Antibodies, Bacterial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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