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Serum soluble urokinase plasminogen activator receptor (suPAR) in early pregnancy prior to clinical onset of preeclampsia.
MedLine Citation:
PMID:  22774918     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective. To examine whether soluble urokinase plasminogen activator receptor (suPAR) in early pregnancy could be a risk marker for later development of preeclampsia. Design. Case-control study. Setting. Hospital based. Population. The study comprised 43 pregnant women developing preeclampsia (cases) and 86 pregnant women not developing the disorder (controls). Each case was matched with two controls with respect to pre-pregnancy body mass index (BMI), gestational age at time of blood collection, storage time of blood samples and maternal age. Methods. The samples had been taken predominantly in first trimester as part of a routine serological screening for rubella, HIV and toxoplasmosis of Norwegian pregnant women, and were analyzed by a commercially available enzyme-linked immunosorbent suPARnostic(®) assay kit (ELISA, Virogates, Copenhagen, Denmark). Results. There was no significant difference between median suPAR levels in women who subsequently developed preeclampsia and those who did not (4.5 in case vs. 4.3 ng/mL in control group, p = 0.49). The suPAR levels were relatively high as compared to levels in non-pregnant women reflecting some general physiological responsiveness associated to pregnancy irrespective of preeclampsia. The suPAR level was not related to maternal BMI, maternal age or sample storage time, nor did it show any association with the following fetal characteristics: body weight, body length, placental weight, delivery method or gender. Conclusion. suPAR did not appear to be a useful early pre-clinical marker of preeclampsia.
Authors:
Nancy Odden; Tore Henriksen; Lars Mørkrid
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-6
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2012 Nordic Federation of Societies of Obstetrics and Gynecology.
Affiliation:
Department of Medical Biochemistry, Oslo University Hospital, Rikshospitalet, Oslo Institute of Clinical Biochemistry, Institute of Clinical Medicine, University of Oslo, Oslo Department of Gynecology and Obstetrics, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
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