| Serum soluble interleukin-2 receptor, interleukin-6, and tumor necrosis factor-alpha levels in children with celiac disease: response to treatment. | |
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MedLine Citation:
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PMID: 12394376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: T-cell mediated immune response to dietary gluten and cytokines release are important for the enteropathy seen in celiac disease. We investigated the serum levels of soluble interleukin-2 receptor, interleukin-6, and tumor necrosis factor-alpha in celiac children before and after gluten exclusion. METHODS: Cytokine levels were determined using enzyme immunoassay in serum from 12 untreated celiac patients, 16 treated celiac patients on a gluten-free diet for at least two years, and from 26 control children. Eight of 12 untreated patients were also investigated at 6 and 12 months after gluten exclusion. Serum IgA antiendomysium antibodies were also assayed by indirect immunofluorescence. RESULTS: Soluble interleukin-2 receptor and interleukin-6 levels were significantly increased in untreated celiac patients compared with treated and control children. There was no difference in the tumor necrosis factor-alpha levels between the groups. Soluble interleukin-2 receptor levels were the only ones significantly decreased at 12 months after gluten exclusion. However, soluble interleukin-2 receptor and interleukin-6 levels at 12 months were significantly higher compared with controls. Antiendomysium antibodies had a diagnostic sensitivity of 100% and the titers decreased significantly after 12 months of gluten exclusion. A significant positive correlation was found between antiendomysium antibody titers with both soluble interleukin-2 receptor and interleukin-6 values. CONCLUSIONS: The serum soluble interleukin-2 receptor and interleukin-6 levels may be used as a noninvasive measure of celiac disease activity and response to treatment. |
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Authors:
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Ceres C Romaldini; Dorina Barbieri; Thelma S Okay; Roberto Raiz; Eduardo L R Cançado |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pediatric gastroenterology and nutrition Volume: 35 ISSN: 0277-2116 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-23 Completed Date: 2003-03-04 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 513-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Faculty of Medicine, University of São Paulo, Brazil. jhroma@netpoint.com.br |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Autoantibodies / blood Celiac Disease / blood*, diagnosis, diet therapy, immunology Child Child, Preschool Enzyme-Linked Immunosorbent Assay Female Fluorescent Antibody Technique, Indirect Gliadin / immunology Glutens / administration & dosage, immunology* Humans Immunity, Cellular Immunoglobulin A / blood Infant Interleukin-6 / blood* Male Receptors, Interleukin-2 / blood* Tumor Necrosis Factor-alpha / analysis*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Immunoglobulin A; 0/Interleukin-6; 0/Receptors, Interleukin-2; 0/Tumor Necrosis Factor-alpha; 8002-80-0/Glutens; 9007-90-3/Gliadin |
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