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Serum soluble α-Klotho in hemodialysis patients.
MedLine Citation:
PMID:  22551879     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background: The extracellulardomain of Klotho is cleaved and releasedinto various extracellular fluids, suchas blood, urine, and cerebrospinal fluid, assoluble α-Klotho (sαKl). Methods: We measuredsαKl in 53 hemodialysis patients and20 healthy controls to examine its role inmineral metabolism. Results: The sαKl levelof the hemodialysis patients was 430 pg/ml (386 - 540 pg/ml, which was lower than thatof healthy controls 740 pg/ml (550 - 913 pg/ml, p < 0.01). The serum sαKl level showeda positive correlation with serum phosphorus (P) (σ = 0.33, p = 0.014), while serum corrected Ca tended to be negatively correlatedwith sαKl (σ = -0.26, p = 0.06). Both parametersshowed the same trends in healthysubjects. However, there was no significantassociation between serum sαKl and age (σ= 0.21, p = 0.14), intact PTH (σ = -0.08, p= 0.55), whole PTH (σ = -0.08, p = 0.59), or FGF23 (σ = -0.07, p = 0.62). Multipleregression analysis showed that P was independentlyassociated with the serum sαKl levels (total adjusted R2 = 0.18, p = 0.02). Conclusions: The sαKl level was lower inhemodialysis patients than in healthy persons. Serum P level was independently associatedwith the serum sαKl level.
Authors:
Keitaro Yokoyama; Akihiko Imura; Ichiro Ohkido; Yukio Maruyama; Yuji Yamazaki; Hisashi Hasegawa; Jun Urae; Hiroshi Sekino; Yoâ Ichi Nabeshima; Tatsuo Hosoya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nephrology     Volume:  77     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  347-51     Citation Subset:  IM    
Affiliation:
Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Biologics Research Laboratories, Kyowa Hokko Kirin Co. Ltd., Tokyo, Kojin-kai Kimachi Hospital, Sendai Miyagi and Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation, Saitama, Japan.
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