Document Detail


Serum soluble HLA class I antigen levels in hemodialysis patients and following renal transplantation.
MedLine Citation:
PMID:  7573185     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We measured the serum levels of soluble HLA class I antigen (sHLA-I) to evaluate the immune status of uremia and following renal transplantation. Twenty-one hemodialysis (HD) patients had serum samples collected for sHLA-I analysis before and after HD and also during the initial posttransplant period. The serum sHLA-I levels in patients undergoing HD were higher than in the normal controls (574.8 +/- 431.1 vs. 415.6 +/- 256.1 ng/ml, p < 0.05). In the HD patients, HD duration was not correlated with serum sHLA-I levels (r = 0.01, p > 0.05), and pre- and post-HD serum sHLA-I levels were not significantly different (574.8 +/- 431.1 vs. 568.3 +/- 398.4 ng/ml, p > 0.05). After successful renal transplantation, the serum sHLA-I levels decreased significantly (574.8 +/- 431.1 vs. 226.7 +/- 202.8 ng/ml, p = 0.0001) but increased significantly during the rejection period as compared to the prerejection period (642.8 +/- 296.1 vs. 305.5 +/- 194.7 ng/ml, p = 0.0002). In conclusion, sHLA-I levels are stable in uremic status and can be used as a parameter for monitoring acute graft rejection in renal transplantation.
Authors:
C W Yang; T G Kim; Y S Kim; H Han; Y S Chang; Y S Yoon; B K Bang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of nephrology     Volume:  15     ISSN:  0250-8095     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  1995  
Date Detail:
Created Date:  1995-11-22     Completed Date:  1995-11-22     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  290-4     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Catholic University Medical College, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Enzyme-Linked Immunosorbent Assay
Female
HLA Antigens / blood*
Humans
Kidney Transplantation / immunology*
Male
Middle Aged
Renal Dialysis*
Uremia / immunology*,  therapy
Chemical
Reg. No./Substance:
0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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