Document Detail

Serum sodium concentration and intraventricular hemorrhage in premature infants.
MedLine Citation:
PMID:  2396615     Owner:  NLM     Status:  MEDLINE    
Recent data suggest that early loss of brain tissue water content, ie, decreased extravascular cerebral tissue pressure, may play a role in the pathogenesis of germinal matrix/intraventricular hemorrhage in the premature newborn. This study examines the relationship between the concentration of serum sodium and germinal matrix/intraventricular hemorrhage in 299 premature infants with birth weights of less than 1500 g during the first 4 days of life. Intraventricular hemorrhage developed in 34 (32%) of the 106 infants with maximum serum sodium levels of 145 mmol/L or less and in 54 (28%) of 193 infants whose highest serum sodium levels were greater than 145 mmol/L (chi 2 = 0.37). These data suggest that concentrations of serum sodium greater than 145 mmol/L are not associated with an increased risk of germinal matrix/intraventricular hemorrhage in the premature newborn. Consequently, more liberal administration of fluids to maintain extravascular cerebral tissue pressure is unlikely to reduce the incidence of germinal matrix hemorrhage/intraventricular hemorrhage.
B A Lupton; E H Roland; M F Whitfield; A Hill
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  144     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-10-05     Completed Date:  1990-10-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1019-21     Citation Subset:  AIM; IM    
Division of Neonatology, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Birth Weight / physiology
Cerebral Cortex / physiology
Cerebral Hemorrhage / etiology*
Dehydration / complications*
Hypernatremia / complications*
Infant, Low Birth Weight / blood
Infant, Newborn
Infant, Premature / blood*
Infant, Premature, Diseases* / blood
Intracranial Pressure
Sodium / blood*
Reg. No./Substance:

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