Document Detail

Serum signaling factors and spheroids.
MedLine Citation:
PMID:  11033299     Owner:  NLM     Status:  MEDLINE    
Normal epithelial cells grow as a sheet-like structure. Upon malignant transformation, epithelial cells grow as multicell aggregates. Adopted in tissue culture, most tumor cells revert to adherent monolayer. In tissue culture, as early as 1958, anchorage-independent multicellular spheroid cancer cells have been shown to revert to adherent monolayer in response to extracellular serum signaling factors. Such serum signaling factors have not yet been characterized. Recent studies reveal that the conversion of adherent monolayer to multicellular spheroids is also mediated by serum signaling factors such as carcinoembryonal antigen, interferon-gamma, insulin-like growth factor-II, heregulin beta1 and plasmin. The reports provide a new approach to investigate the regulatory system of tumor cell growth pattern as well as the effect of the change in growth pattern on various cellular functions.
M H Chun
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical reviews in oncology/hematology     Volume:  36     ISSN:  1040-8428     ISO Abbreviation:  Crit. Rev. Oncol. Hematol.     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-01-09     Completed Date:  2001-01-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8916049     Medline TA:  Crit Rev Oncol Hematol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  89-98     Citation Subset:  IM    
Bioeast, New York, NY 10128, USA.
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MeSH Terms
Blood Proteins / metabolism*
Cell Culture Techniques / methods
Cell Transformation, Neoplastic*
Epithelial Cells / metabolism,  pathology*
Signal Transduction
Spheroids, Cellular / metabolism,  pathology*
Reg. No./Substance:
0/Blood Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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