| Serum selenium and serum lipids in US adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004. | |
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MedLine Citation:
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PMID: 20102763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: High selenium has been recently associated with several cardiovascular and metabolic risk factors including diabetes, blood pressure and lipid levels. We evaluated the association of serum selenium with fasting serum lipid levels in the National Health and Nutrition Examination Survey (NHANES) 2003-2004, the most recently available representative sample of the US population that measured selenium levels. METHODS: Cross-sectional analysis of 1159 adults>or=40 years old from NHANES 2003-2004. Serum selenium was measured by inductively coupled plasma-dynamic reaction cell-mass spectrometry. Fasting serum total cholesterol, triglycerides, and HDL cholesterol were measured enzymatically and LDL cholesterol was calculated. RESULTS: Mean serum selenium was 136.7 microg/L. The multivariable adjusted average differences (95% confidence interval) comparing the highest (>or=147 microg/L) to the lowest (<124 microg/L) selenium quartiles were 18.9 (9.9, 28.0) mg/dL for total cholesterol, 12.7 (3.3, 22.2) mg/dL for LDL cholesterol, 3.9 (0.4, 7.5)mg/dL for HDL cholesterol, and 11.5 (-7.6, 30.7) mg/dL for triglycerides. In spline regression models, total and LDL cholesterol levels increased progressively with increasing selenium concentrations. HDL cholesterol increased with selenium but reached a plateau above 120 microg/L of serum selenium (20th percentile). The triglyceride-selenium relationship was U-shaped. CONCLUSION: In US adults, high serum selenium concentrations were associated with increased serum concentrations of total and LDL cholesterol. Selenium was associated with increasing HDL cholesterol only at low selenium levels. Given increasing trends in dietary selenium intake and supplementation, the causal mechanisms underlying these associations need to be fully characterized. |
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Authors:
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Martin Laclaustra; Saverio Stranges; Ana Navas-Acien; Jose M Ordovas; Eliseo Guallar |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-01-11 |
Journal Detail:
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Title: Atherosclerosis Volume: 210 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-12-06 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 643-8 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Cardiovascular Epidemiology and Population Genetics, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cross-Sectional Studies Female Health Surveys Humans Lipids / blood* Male Middle Aged Nutrition Surveys* Nutritional Status Selenium / blood* United States |
| Grant Support | |
ID/Acronym/Agency:
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DK075030/DK/NIDDK NIH HHS; ES012673/ES/NIEHS NIH HHS; R01 ES012673-01/ES/NIEHS NIH HHS; R01 ES015597-01A2/ES/NIEHS NIH HHS; R01 HL070299-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 7782-49-2/Selenium |
| Comments/Corrections | |
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