Document Detail

Serum selenium and glutathione peroxidase concentrations in Iranian patients with angiography-defined coronary artery disease.
MedLine Citation:
PMID:  18586758     Owner:  NLM     Status:  MEDLINE    
This study investigated the relationship between serum selenium (Se) and glutathione peroxidase (GPx) levels and the presence of coronary artery disease (CAD) among Iranian patients. Three groups were compared: patients undergoing angiography with angiographically defined CAD, individuals with a normal angiogram, and apparently healthy controls with no evidence of overt CAD. Anthropometric measurements, blood pressure, fasting blood glucose and lipid profiles, serum Se and GPx measurements, and angiographic assessment were carried out using standard protocols. Mean serum Se concentrations were not significantly different between patients with and without CAD and the control group. The mean value of serum GPx in the control group was significantly higher than in patients with or without CAD. Selenium status did not differentiate between patients with and without CAD, which may be related to the fact that angiography is not a very sensitive index of global atherosclerosis, and it is possible that patients who were CAD negative by angiogram still have significant disease. It may also be that Se is not a good marker of CAD.
Seyyed Mohammad Reza Parizadeh; Mohsen Moohebati; Fahimeh Ghafoori; Majid Ghayour-Mobarhan; Seyyed Mohammad Reza Kazemi-Bajestani; Shima Tavallaie; Mohsen Azimi-Nezhad; Gordon A Ferns
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-06-27
Journal Detail:
Title:  Angiology     Volume:  60     ISSN:  1940-1574     ISO Abbreviation:  Angiology     Publication Date:    2009 Apr-May
Date Detail:
Created Date:  2009-04-20     Completed Date:  2009-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  186-91     Citation Subset:  IM    
Department of Nutrition and Biochemistry, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
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MeSH Terms
Biological Markers / blood
Coronary Angiography / methods*
Coronary Artery Disease / blood*,  epidemiology,  radiography
Follow-Up Studies
Glutathione Peroxidase / blood*
Iran / epidemiology
Middle Aged
Risk Factors
Selenium / blood*
Spectrophotometry, Atomic
Reg. No./Substance:
0/Biological Markers; 7782-49-2/Selenium; EC Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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