Document Detail

Serum selenium concentrations and hypertension in the US Population.
MedLine Citation:
PMID:  20031863     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Selenium is an antioxidant micronutrient with potential interest for cardiovascular disease prevention. Few studies have evaluated the association between selenium and hypertension, with inconsistent findings. We explored the relationship of serum selenium concentrations with blood pressure and hypertension in a representative sample of the US population.
METHODS AND RESULTS: We undertook a cross-sectional analysis of 2638 adults > or =40 years old who participated in the 2003 to 2004 National Health and Nutrition Examination Survey. Serum selenium was measured by inductively coupled plasma-dynamic reaction cell-mass spectrometry. Hypertension was defined as blood pressure > or =140/90 mm Hg or current use of antihypertensive medication. Mean serum selenium was 137.1 microg/L. The multivariable adjusted differences (95% CIs) in blood pressure levels comparing the highest (> or =150 microg/L) to the lowest (<122 microg/L) quintile of serum selenium were 4.3 (1.3 to 7.4), 1.6 (-0.5 to 3.7), and 2.8 (0.8 to 4.7) mm Hg for systolic, diastolic, and pulse pressure, respectively. The corresponding odds ratio for hypertension was 1.73 (1.18 to 2.53). In spline regression models, blood pressure levels and the prevalence of hypertension increased with increasing selenium concentrations up to 160 microg/L.
CONCLUSIONS: High serum selenium concentrations were associated with higher prevalence of hypertension. These findings call for a thorough evaluation of the risks and benefits associated with high selenium status in the United States.
Martin Laclaustra; Ana Navas-Acien; Saverio Stranges; Jose M Ordovas; Eliseo Guallar
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-06-16
Journal Detail:
Title:  Circulation. Cardiovascular quality and outcomes     Volume:  2     ISSN:  1941-7705     ISO Abbreviation:  Circ Cardiovasc Qual Outcomes     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-12-24     Completed Date:  2010-03-26     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  101489148     Medline TA:  Circ Cardiovasc Qual Outcomes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  369-76     Citation Subset:  IM    
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MeSH Terms
Antihypertensive Agents / therapeutic use
Blood Pressure
Cross-Sectional Studies
Hypertension / blood*,  drug therapy,  epidemiology*
Middle Aged
Multivariate Analysis
Nutrition Surveys
Risk Factors
Selenium / blood*
United States / epidemiology
Grant Support
1 R01 ES012673/ES/NIEHS NIH HHS; R01 ES012673/ES/NIEHS NIH HHS; R01 ES012673-04/ES/NIEHS NIH HHS; R01 ES015597/ES/NIEHS NIH HHS; R01 ES015597-01A2/ES/NIEHS NIH HHS; R01 HL070299/HL/NHLBI NIH HHS; R01 HL070299-05/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Antihypertensive Agents; H6241UJ22B/Selenium

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