Document Detail

Serum screening for Down syndrome and adverse pregnancy outcomes: a case-controlled study.
MedLine Citation:
PMID:  10694681     Owner:  NLM     Status:  MEDLINE    
The relationship between adverse perinatal outcomes in women with false positive biochemical screening test for Down syndrome was investigated in a retrospective case-controlled study. A cohort of 4000 women who booked for routine antenatal care and opted for biochemical screening over a 22 month period was obtained. The pregnancy outcome data of 272 women with a false positive screening test for Down syndrome (risk >1 in 250) at 15-18 weeks of gestation (study group) were compared with data from 272 age and gestation matched controls with a negative Down syndrome screening test from the same population. The frequency of normal and adverse perinatal outcomes, including pre-eclampsia, isolated intrauterine growth restriction, spontaneous preterm labour and stillbirth was recorded. The incidence of adverse pregnancy outcomes was 11.9% in the study group and 8.6% in the control group. The estimated odds ratio of an abnormal outcome in the study group was 1.41 (95% CI-0.790, 2.55). The observed difference between proportion was 0.0324 (95% CI-0.022, 0.083; p=0.40). These data identify no evidence for a strong association between a false positive Down syndrome screening test result and subsequent adverse perinatal outcomes in the general population.
R Ogle; E Jauniaux; G S Pahal; E Dell; A Sheldrake; C Rodeck
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  20     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-27     Completed Date:  2000-03-27     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  96-9     Citation Subset:  IM    
Copyright Information:
Copyright 2000 John Wiley & Sons, Ltd.
Academic Department of Obstetrics and Gynaecology, University College London Hospitals, London, UK.
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MeSH Terms
Case-Control Studies
Cohort Studies
Down Syndrome / diagnosis*
False Positive Reactions
Fetal Death / epidemiology
Fetal Growth Retardation / epidemiology
Gestational Age
Obstetric Labor, Premature / epidemiology
Odds Ratio
Pre-Eclampsia / epidemiology
Pregnancy Outcome*
Prenatal Diagnosis*

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