| Serum salusin-alpha levels are decreased and correlated negatively with carotid atherosclerosis in essential hypertensive patients. | |
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MedLine Citation:
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PMID: 18497465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Salusin-alpha is a new bioactive peptide with mild hypotensive and bradycardic effects. Our recent study showed that salusin-alpha suppresses foam cell formation in human monocyte-derived macrophages by down-regulating acyl-CoA:cholesterol acyltransferase-1, contributing to its anti-atherosclerotic effect. To clarify the clinical implications of salusin-alpha in hypertension and its complications, we examined the relationship between serum salusin-alpha levels and carotid atherosclerosis in hypertensive patients. The intima-media thickness (IMT) and plaque score in the carotid artery, blood pressure, serum levels of salusin-alpha, and atherosclerotic parameters were determined in 70 patients with essential hypertension and in 20 normotensive controls. There were no significant differences in age, gender, body mass index, fasting plasma glucose level, or serum levels of high-sensitive C-reactive protein, high- or low-density lipoprotein (LDL) cholesterol, small dense LDL, triglycerides, lipoprotein(a), or insulin between the two groups. Serum salusin-alpha levels were significantly lower in hypertensive patients than in normotensive controls. The plasma urotensin-II level, maximal IMT, plaque score, systolic and diastolic blood pressure, and homeostasis model assessment for insulin resistance (HOMA-IR) were significantly greater in hypertensive patients than in normotensive controls. In all subjects, maximal IMT was significantly correlated with age, systolic blood pressure, LDL cholesterol, urotensin-II, salusin-alpha, and HOMA-IR. Forward stepwise multiple linear regression analysis revealed that salusin-alpha levels had a significantly independent and negative association with maximal IMT. Serum salusin-alpha levels were significantly lower in accordance with the severity of plaque score. Our results suggest that the decrease in serum salusin-alpha, an anti-atherogenic peptide, may be associated with carotid atherosclerosis in hypertensive patients. |
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Authors:
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Takuya Watanabe; Toshiaki Suguro; Kengo Sato; Takatoshi Koyama; Masaharu Nagashima; Syuusuke Kodate; Tsutomu Hirano; Mitsuru Adachi; Masayoshi Shichiri; Akira Miyazaki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 31 ISSN: 0916-9636 ISO Abbreviation: Hypertens. Res. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-05-23 Completed Date: 2008-07-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: Japan |
Other Details:
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Languages: eng Pagination: 463-8 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan. watanabemd@med.showa-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Blood Pressure / physiology Carotid Artery Diseases / blood*, pathology Carotid Stenosis / pathology Case-Control Studies Cholesterol, LDL / blood Female Humans Hypertension / blood* Intercellular Signaling Peptides and Proteins / blood* Linear Models Male Middle Aged Severity of Illness Index Tunica Intima / ultrasonography Tunica Media / ultrasonography Urotensins / blood |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; 0/Intercellular Signaling Peptides and Proteins; 0/TOR2A protein, human; 0/Urotensins; 9047-55-6/urotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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