| Serum retinol concentrations in children are affected by food sources of beta-carotene, fat intake, and anthelmintic drug treatment. | |
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MedLine Citation:
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PMID: 9734739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The provision of vitamin A in food sources of beta-carotene is an alternative to the distribution of high-dose capsules. To examine factors that may influence the success of food-based programs, a study was carried out in Sumatra, Indonesia, of the effect of food sources of beta-carotene, extra dietary fat, and Ascaris lumbricoides infection on serum retinol concentrations in children. Meals and snacks with various amounts of beta-carotene and fat were fed at midday to children 3-6 y of age for 3 wk. Some groups of children were dewormed with the anthelmintic levamisole before the feeding period, whereas others remained infected. Results showed that the incorporation of beta-carotene sources (mainly in the form of red sweet potatoes) into the meal significantly increased serum retinol concentrations. The greatest rise in serum retinol occurred when meals contained added beta-carotene sources and added fat and the children were dewormed. Adding more fat to the meal and deworming the children caused a rise in serum retinol similar to that seen when feeding additional beta-carotene sources. Moreover, the effects of fat and deworming together were additive to the effects of additional beta-carotene sources. When the meal contained additional beta-carotene sources, added fat caused a further improvement in serum retinol concentrations but only if A. lumbricoides infection was low. These studies indicated that food-based interventions in vitamin A-deficient areas might be successful and that other interventions such as increasing dietary fat concentrations and anthelmintic treatment should be considered along with increasing consumption of beta-carotene-rich food. |
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Authors:
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F Jalal; M C Nesheim; Z Agus; D Sanjur; J P Habicht |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 68 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-09-29 Completed Date: 1998-09-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 623-9 Citation Subset: AIM; IM |
Affiliation:
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Cornell University, Division of Nutritional Sciences, Ithaca, NY 14853, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antinematodal Agents / pharmacology, therapeutic use* Ascariasis / drug therapy* Ascaris lumbricoides* Child, Preschool Confounding Factors (Epidemiology) Diet* Dietary Fats / administration & dosage*, pharmacology Humans Levamisole / pharmacology, therapeutic use* Parasite Egg Count Vitamin A / blood* beta Carotene / administration & dosage*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antinematodal Agents; 0/Dietary Fats; 11103-57-4/Vitamin A; 14769-73-4/Levamisole; 7235-40-7/beta Carotene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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