Document Detail

Serum retinol concentrations in children are affected by food sources of beta-carotene, fat intake, and anthelmintic drug treatment.
MedLine Citation:
PMID:  9734739     Owner:  NLM     Status:  MEDLINE    
The provision of vitamin A in food sources of beta-carotene is an alternative to the distribution of high-dose capsules. To examine factors that may influence the success of food-based programs, a study was carried out in Sumatra, Indonesia, of the effect of food sources of beta-carotene, extra dietary fat, and Ascaris lumbricoides infection on serum retinol concentrations in children. Meals and snacks with various amounts of beta-carotene and fat were fed at midday to children 3-6 y of age for 3 wk. Some groups of children were dewormed with the anthelmintic levamisole before the feeding period, whereas others remained infected. Results showed that the incorporation of beta-carotene sources (mainly in the form of red sweet potatoes) into the meal significantly increased serum retinol concentrations. The greatest rise in serum retinol occurred when meals contained added beta-carotene sources and added fat and the children were dewormed. Adding more fat to the meal and deworming the children caused a rise in serum retinol similar to that seen when feeding additional beta-carotene sources. Moreover, the effects of fat and deworming together were additive to the effects of additional beta-carotene sources. When the meal contained additional beta-carotene sources, added fat caused a further improvement in serum retinol concentrations but only if A. lumbricoides infection was low. These studies indicated that food-based interventions in vitamin A-deficient areas might be successful and that other interventions such as increasing dietary fat concentrations and anthelmintic treatment should be considered along with increasing consumption of beta-carotene-rich food.
F Jalal; M C Nesheim; Z Agus; D Sanjur; J P Habicht
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  68     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-09-29     Completed Date:  1998-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  623-9     Citation Subset:  AIM; IM    
Cornell University, Division of Nutritional Sciences, Ithaca, NY 14853, USA.
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MeSH Terms
Antinematodal Agents / pharmacology,  therapeutic use*
Ascariasis / drug therapy*
Ascaris lumbricoides*
Child, Preschool
Confounding Factors (Epidemiology)
Dietary Fats / administration & dosage*,  pharmacology
Levamisole / pharmacology,  therapeutic use*
Parasite Egg Count
Vitamin A / blood*
beta Carotene / administration & dosage*,  pharmacology
Reg. No./Substance:
0/Antinematodal Agents; 0/Dietary Fats; 11103-57-4/Vitamin A; 14769-73-4/Levamisole; 7235-40-7/beta Carotene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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