| Serum retinoids in retinitis pigmentosa patients treated with vitamin A. | |
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MedLine Citation:
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PMID: 8871145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients with retinitis pigmentosa have been suggested to benefit from treatment with moderate doses of retinyl palmitate. Retinyl palmitate is not an active retinoid in itself but is metabolised to active components in the body. To find out which metabolites of retinyl palmitate were formed and at which concentrations, we measured the concentrations of retinol, retinyl palmitate, retinoic acids and tocopherol in serum of patients treated with oral retinyl palmitate for retinitis pigmentosa. METHODS: Nine male patients and one female diagnosed as having retinitis pigmentosa after a complete ophthalmological examination including a full-field electroretinogram were given vitamin A at their own request as one daily morning dose of 16600 IU vitamin A. Blood samples were obtained before and after > 2 weeks of treatment. The concentrations of retinoids and tocopherol were measured with established methods. RESULTS: The patients were not deficient in vitamin A or vitamin E as judged from the serum vitamin concentrations. Treatment with retinyl palmitate significantly increased the serum concentration of retinyl palmitate and of 13-cis-retinoic acid but not of retinol, tocopherol or all-trans-retinoic acid. CONCLUSIONS: Neither retinyl palmitate nor 13-cis-retinoic acid, are known to be biologically active. However, 13-cis-retinoic acid can isomerise to the active vitamin A derivative, all-trans-retinoic acid. It is suggested that patients may be treated with a small dose of 13-cis-retinoic acid instead, to avoid the relatively long metabolic detour from retinyl palmitate. |
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Authors:
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G A Fex; S Andréasson; B Ehinger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Volume: 234 Suppl 1 ISSN: 0721-832X ISO Abbreviation: Graefes Arch. Clin. Exp. Ophthalmol. Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1997-01-16 Completed Date: 1997-01-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8205248 Medline TA: Graefes Arch Clin Exp Ophthalmol Country: GERMANY |
Other Details:
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Languages: eng Pagination: S18-21 Citation Subset: IM |
Affiliation:
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Department of Clinical Chemistry, Lund University Hospital, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Anticarcinogenic Agents / blood Chromatography, High Pressure Liquid Electroretinography Female Humans Male Middle Aged Retinitis Pigmentosa / blood*, drug therapy, physiopathology Retinoids / blood* Tretinoin / analogs & derivatives, blood Vitamin A / analogs & derivatives, blood, therapeutic use* Vitamin E / blood |
| Chemical | |
Reg. No./Substance:
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0/Anticarcinogenic Agents; 0/Retinoids; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 302-79-4/Tretinoin; 38030-57-8/4-oxoretinoic acid; 79-81-2/retinol palmitate |
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