| Serum resistin: physiology, pathophysiology and implications for heart failure. | |
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MedLine Citation:
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PMID: 20550478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Resistin, a 12.5-kDa polypeptide, has been associated with both insulin resistance and inflammation in animal models. Although initially discovered in the adipocytes, it has subsequently been found in other tissues. In humans, controversy still exists regarding the role of resistin but serum resistin concentration has been correlated with risk factors for coronary heart disease, renal dysfunction and outcomes among stroke patients. Both inflammation and insulin resistance are associated with the development of incident heart failure, with worse outcomes among those with prevalent cardiomyopathy. Therefore, it is interesting to note that recent literature suggests a significant relationship between serum resistin concentrations and heart failure. In this article, we discuss the physiology, pathophysiology, and the direct and indirect role of resistin in determining heart failure risk and worse outcomes among these patients. Some of the salient points reviewed include the possible association of resistin with hyperglycemia and substrate metabolism, inflammation through TNF-alpha and direct cardiac effects. |
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Authors:
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Vikas Bhalla; Andreas Kalogeropoulos; Vasiliki Georgiopoulou; Javed Butler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Biomarkers in medicine Volume: 4 ISSN: 1752-0371 ISO Abbreviation: Biomark Med Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-16 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101312535 Medline TA: Biomark Med Country: England |
Other Details:
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Languages: eng Pagination: 445-52 Citation Subset: IM |
Affiliation:
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Cardiology Division, Emory University Hospital, 1365 Clifton Road NE, Suite AT 430, Atlanta, GA 30322, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Heart Failure
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blood,
etiology* Humans Inflammation / complications Insulin Resistance Resistin / blood*, physiology Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Resistin |
| Comments/Corrections | |
Erratum In:
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Biomark Med.2010 Aug;4(4):643 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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