Document Detail


Serum resistin: physiology, pathophysiology and implications for heart failure.
MedLine Citation:
PMID:  20550478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Resistin, a 12.5-kDa polypeptide, has been associated with both insulin resistance and inflammation in animal models. Although initially discovered in the adipocytes, it has subsequently been found in other tissues. In humans, controversy still exists regarding the role of resistin but serum resistin concentration has been correlated with risk factors for coronary heart disease, renal dysfunction and outcomes among stroke patients. Both inflammation and insulin resistance are associated with the development of incident heart failure, with worse outcomes among those with prevalent cardiomyopathy. Therefore, it is interesting to note that recent literature suggests a significant relationship between serum resistin concentrations and heart failure. In this article, we discuss the physiology, pathophysiology, and the direct and indirect role of resistin in determining heart failure risk and worse outcomes among these patients. Some of the salient points reviewed include the possible association of resistin with hyperglycemia and substrate metabolism, inflammation through TNF-alpha and direct cardiac effects.
Authors:
Vikas Bhalla; Andreas Kalogeropoulos; Vasiliki Georgiopoulou; Javed Butler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biomarkers in medicine     Volume:  4     ISSN:  1752-0371     ISO Abbreviation:  Biomark Med     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-16     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312535     Medline TA:  Biomark Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  445-52     Citation Subset:  IM    
Affiliation:
Cardiology Division, Emory University Hospital, 1365 Clifton Road NE, Suite AT 430, Atlanta, GA 30322, USA.
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MeSH Terms
Descriptor/Qualifier:
Heart Failure / blood,  etiology*
Humans
Inflammation / complications
Insulin Resistance
Resistin / blood*,  physiology
Risk Factors
Chemical
Reg. No./Substance:
0/Resistin
Comments/Corrections
Erratum In:
Biomark Med.2010 Aug;4(4):643

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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