Document Detail

Serum relaxin in patients with invasive mole, choriocarcinoma and persistent trophoblastic disease.
MedLine Citation:
PMID:  3030714     Owner:  NLM     Status:  MEDLINE    
Human chorionic gonadotropin (hCG) is considered to be one of the factors which regulate relaxin secretion in humans. Serum immunoreactive relaxin levels are increased and are detectable by radioimmunoassay both in normal and molar pregnancy. Circulating hCG levels are increased in trophoblastic disease. In the present study, relaxin and hCG levels were sequentially measured in patients with invasive mole, choriocarcinoma and persistent trophoblastic disease. Serum relaxin levels were detectable by radioimmunoassay in these patients before treatment, though they were significantly lower than in normal pregnancy. The corpus luteum of pregnancy is the main source of circulating relaxin in normal pregnancy. The existence of a corpus luteum was confirmed in the 2 patients who underwent laparotomy. Consequently, the corpus luteum may also be the main source of circulating relaxin in trophoblastic disease. Parallel changes in hCG and relaxin levels were observed during the courses of trophoblastic disease. The finding suggests that relaxin secretion is dependent on hCG stimulation in trophoblastic disease in the presence of corpus luteum.
K Seki; T Uesato; K Kato
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Endocrinologia japonica     Volume:  33     ISSN:  0013-7219     ISO Abbreviation:  Endocrinol. Jpn.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1987-04-27     Completed Date:  1987-04-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376546     Medline TA:  Endocrinol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  727-33     Citation Subset:  IM    
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MeSH Terms
Choriocarcinoma / blood*
Chorionic Gonadotropin / blood
Corpus Luteum / physiology
Hydatidiform Mole, Invasive / blood*
Relaxin / blood*,  metabolism
Trophoblastic Neoplasms / blood*
Uterine Neoplasms / blood*
Reg. No./Substance:
0/Chorionic Gonadotropin; 9002-69-1/Relaxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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