Document Detail

Serum relaxin as a potential marker for preterm labour.
MedLine Citation:
PMID:  1581273     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether high serum relaxin concentrations in the 30th week of pregnancy were associated with preterm labour. DESIGN: Case-control study. SETTING: Two antenatal clinics of the Department of Obstetrics and Gynecology University Hospital of Aarhus. SUBJECTS: A cohort of 991 women (82% of 1203 eligible) in the 30th week of pregnancy attending one of the two antenatal clinics. The cases comprised 23 (2.4%) women without pre-eclampsia or small for gestational age babies, who were delivered spontaneously before 37 completed weeks gestation. The control group of 46 women was randomly selected from the rest of the cohort, all of them were delivered at term. INTERVENTIONS: Blood samples were collected at 30 weeks gestation and stored for analysis. MAIN OUTCOME MEASURES: Serum relaxin concentrations estimated by ELISA technique, length of gestation at delivery. RESULTS: The mean serum relaxin concentrations in the 30th week of pregnancy was 455 (SD 169) pg/ml and 327 (SD 139) pg/ml in the cases and controls, respectively (P = 0.003, t test). In women with preterm delivery a negative correlation was found between relaxin concentration in the 30th week of pregnancy and the gestational age at parturition (r = -0.53, P = 0.02). CONCLUSION: High relaxin concentrations may be associated with preterm delivery but the present results need confirmation in large scale studies.
L K Petersen; K Skajaa; N Uldbjerg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  99     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-06-16     Completed Date:  1992-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  292-5     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Aarhus Kommunehospital, Denmark.
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MeSH Terms
Biological Markers / blood
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Gestational Age
Obstetric Labor, Premature / blood*
Relaxin / blood*
Reg. No./Substance:
0/Biological Markers; 9002-69-1/Relaxin

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