| Serum concentration/dose ratio of levetiracetam before, during and after pregnancy. | |
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MedLine Citation:
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PMID: 18180176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate changes in levetiracetam (LEV) serum concentration/dose ratio (C/D-ratio) in relation to pregnancy. METHODS: Altogether 21 consecutive pregnancies in 20 women with epilepsy receiving LEV during gestation were studied retrospectively. The main target variable was the C/D-ratio before and during pregnancy, and in the post partum period. Secondary target variables were changes in LEV dose, concomitant use of other antiepileptic drugs and seizure frequency. Student's paired t-test and two-sample t-test for independent samples were used to test for statistically significant changes in C/D-ratio means. RESULTS: Mean C/D-ratio in the third trimester was 50% of the mean C/D-ratio at baseline (p<0.001, n=11). Baseline levels were reached within the first weeks after pregnancy. The interindividual variability was pronounced. CONCLUSIONS: Serum concentrations of LEV declined significantly in the third trimester of pregnancy and increased rapidly after delivery. |
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Authors:
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Andreas Austgulen Westin; Arne Reimers; Grethe Helde; Karl Otto Nakken; Eylert Brodtkorb |
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Publication Detail:
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Type: Journal Article Date: 2008-01-03 |
Journal Detail:
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Title: Seizure : the journal of the British Epilepsy Association Volume: 17 ISSN: 1059-1311 ISO Abbreviation: Seizure Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-03 Completed Date: 2008-07-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9306979 Medline TA: Seizure Country: England |
Other Details:
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Languages: eng Pagination: 192-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacology, St. Olavs Hospital, Olav Kyrres gate 17, N-7006 Trondheim, Norway. andreas.westin@legemidler.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticonvulsants / blood*, therapeutic use Epilepsy / blood*, drug therapy Female Humans Piracetam / analogs & derivatives*, blood, therapeutic use Pregnancy / blood*, drug effects Retrospective Studies Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 33996-58-6/etiracetam; 7491-74-9/Piracetam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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