Document Detail

Serum concentration/dose ratio of levetiracetam before, during and after pregnancy.
MedLine Citation:
PMID:  18180176     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate changes in levetiracetam (LEV) serum concentration/dose ratio (C/D-ratio) in relation to pregnancy.
METHODS: Altogether 21 consecutive pregnancies in 20 women with epilepsy receiving LEV during gestation were studied retrospectively. The main target variable was the C/D-ratio before and during pregnancy, and in the post partum period. Secondary target variables were changes in LEV dose, concomitant use of other antiepileptic drugs and seizure frequency. Student's paired t-test and two-sample t-test for independent samples were used to test for statistically significant changes in C/D-ratio means.
RESULTS: Mean C/D-ratio in the third trimester was 50% of the mean C/D-ratio at baseline (p<0.001, n=11). Baseline levels were reached within the first weeks after pregnancy. The interindividual variability was pronounced.
CONCLUSIONS: Serum concentrations of LEV declined significantly in the third trimester of pregnancy and increased rapidly after delivery.
Andreas Austgulen Westin; Arne Reimers; Grethe Helde; Karl Otto Nakken; Eylert Brodtkorb
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Publication Detail:
Type:  Journal Article     Date:  2008-01-03
Journal Detail:
Title:  Seizure     Volume:  17     ISSN:  1059-1311     ISO Abbreviation:  Seizure     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-07-02     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  192-8     Citation Subset:  IM    
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MeSH Terms
Anticonvulsants / blood*,  therapeutic use
Epilepsy / blood*,  drug therapy
Piracetam / analogs & derivatives*,  blood,  therapeutic use
Pregnancy / blood*,  drug effects
Retrospective Studies
Time Factors
Reg. No./Substance:
0/Anticonvulsants; 230447L0GL/etiracetam; ZH516LNZ10/Piracetam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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