Document Detail

Serum prolidase I activity and some bone metabolic markers in patients with breast cancer: in relation to menopausal status.
MedLine Citation:
PMID:  12810158     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The purpose of this study was to investigate the diagnostic value of some osteoblastic/osteoclastic biochemical markers and serum prolidase I activity in breast cancer (BC). DESIGN AND METHODS: Serum bone gla protein (BGP), prolidase I activity, urinary deoxypyridinoline (Dpy) and calcium excretions were measured, in metastatic and nonmetastatic BC patients, and in 52 healthy women. RESULTS: In patients with metastases, bone turnover markers were found to be significantly higher than those in the control group and in patients without metastases. Serum prolidase activity in patients with and without metastases was also significantly higher than those in the control group, but there was no difference between the two patient groups. CONCLUSIONS: Bone turnover has been suggested to be accelerated in BC patients with the more pronounced osteolytic activation, especially in metastatic state. Serum prolidase in premenopausal period appears to be valuable in discriminating cancer patients from controls. BGP and to a lesser degree of Dpy, may be useful markers for predicting the metastatic bone involvement, as well as for the more cost effective management of BC patients and monitoring the effects of antiresorptive therapy of malignant osteolysis before any metastasis could be detected by other invasive techniques.
Zeynep Ozbek Kir; Pernur Oner; Yildiz Oner Iyidoğan; Sembol Türkmen; Hikmet Koçak; Murat Koşer; Seden Ozbilen Küçücük
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical biochemistry     Volume:  36     ISSN:  0009-9120     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-17     Completed Date:  2004-03-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  289-94     Citation Subset:  IM    
Department of Biochemistry, Istanbul Faculty of Medicine, Istanbull University, Capa, 34093 Istanbul, Turkey.
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MeSH Terms
Amino Acids / urine
Biological Markers / blood,  urine
Bone Neoplasms / secondary*
Breast Neoplasms / blood,  pathology*,  urine
Calcium / urine
Dipeptidases / blood*
Middle Aged
Osteocalcin / blood
Predictive Value of Tests
Reg. No./Substance:
0/Amino Acids; 0/Biological Markers; 104982-03-8/Osteocalcin; 7440-70-2/Calcium; 90032-33-0/deoxypyridinoline; EC 3.4.13.-/Dipeptidases; EC dipeptidase

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