Document Detail

Serum prolactin levels in active multiple sclerosis and during cyclosporin treatment.
MedLine Citation:
PMID:  8410056     Owner:  NLM     Status:  MEDLINE    
Prolactin is essential for immune function. Excess prolactin augments some immune reactions, whereas low serum levels of prolactin inhibit immune function and prevent experimental allergic encephalomyelitis, an animal model of multiple sclerosis (MS). Activated lymphocytes, characteristics of MS, release prolactin. In this study, serum prolactin levels were normal in 35 patients with chronic progressive MS and 19 patients with acute exacerbations. These results suggest it is unlikely that prolactin contributes to the enhanced immune reactivity characteristic of MS. Acute cyclosporin A (CsA) administration increases circulating prolactin levels in animals and might paradoxically augment some immune reactions. We find that chronic CsA therapy for MS does not cause elevations in serum prolactin and should not reverse any therapeutic effect of CsA. Disturbances of prolactin regulation are not characteristic of MS.
A T Reder; M T Lowy
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  117     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-11-01     Completed Date:  1993-11-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  192-6     Citation Subset:  IM    
Department of Neurology, University of Chicago, IL.
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MeSH Terms
Cyclosporine / therapeutic use*
Double-Blind Method
Lymphocyte Activation
Multiple Sclerosis / blood,  drug therapy*
Prolactin / antagonists & inhibitors,  blood*,  physiology
Reg. No./Substance:
59865-13-3/Cyclosporine; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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