| Serum prolactin levels after seizure and syncopal attacks. | |
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MedLine Citation:
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PMID: 10452919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Loss of consciousness and falling are the key features of syncope. Common accompaniments include tonic and myoclonic muscle activity, eye deviations, automatisms, vocalizations and hallucinations that may render the distinction from epileptic seizures difficult. The frequently increased levels of serum prolactin (SPRL) were observed immediately after generalized and complex partial seizures. Presumably, the hormone release is caused by the propagation of epileptic activity, usually from the temporal lobe to the hypothalamic pituitary axis. Numerous reports have demonstrated that the post-ictal SPRL level may be used to differentiate between epileptic and syncopal, non-epileptic attacks. In order to confirm the hypothesis, the SPRL levels were measured in patients with complex partial seizures (CPS) and patients with vaso-vagal syncopal attacks (VVS). The SPRL levels were prospectively measured for each patient as soon as possible after the event (within 1 hour), then 1 hour after the first determination and finally blood was sampled 24 hours later. During the study period (18 months), 18 patients with CPS and 15 patients with VVS were investigated in total. The mean values of SPRL levels in both groups were increased immediately after the event (CPS group: 1142 +/- 305 mIU/l; VVS group: 874 +/- 208 mIU/l). The elevated SPRL levels were found in 14 (78%) patients immediately after CPS and in 9 (60%) patients immediately after VVS. After examining the results of the present study we conclude that the elevated serum prolactin level after an epileptic attack is of no significant value in differential diagnosis between epileptic and vaso-vagal syncopal attacks. |
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Authors:
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I Lusić; I Pintarić; I Hozo; L Boić; V Capkun |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Seizure : the journal of the British Epilepsy Association Volume: 8 ISSN: 1059-1311 ISO Abbreviation: Seizure Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-09-30 Completed Date: 1999-09-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9306979 Medline TA: Seizure Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 218-22 Citation Subset: IM |
Copyright Information:
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Copyright 1999 BEA Trading Ltd. |
Affiliation:
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Clinical Hospital Split, Department of Neurology, Spinciceva 1, Split, 21000, Croatia. ivo.lusic@st.tel.hr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Diagnosis, Differential Epilepsy, Complex Partial / blood*, diagnosis Female Humans Predictive Value of Tests Prolactin / blood* Seizures / blood*, diagnosis Syncope, Vasovagal / blood*, diagnosis |
| Chemical | |
Reg. No./Substance:
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9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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