Document Detail

Serum proinflammatory cytokine levels and white blood cell differential count in patients with different degrees of severity of acute alcoholic pancreatitis.
MedLine Citation:
PMID:  22763297     Owner:  NLM     Status:  MEDLINE    
MATERIAL AND METHODS: Thirty-five patients with the mild form of acute alcoholic pancreatitis (MAAP) were compared to 11 patients with severe acute alcoholic pancreatitis (SAAP). Serum levels of IL-6, IL-8, IL-12p40 and WBC differential count were measured every second day during the first week after admission.
RESULTS: During the course of the study, the average level of IL-6 was significantly (p<0.05) higher in patients with SAAP than in patients with the mild form of the disease (MAAP). Serum levels of IL-8 and IL-12p40 on admission were higher in patients with SAAP than in patients with MAAP but the difference was not statistically significant. Of all the types of WBCs, neutrophils were significantly (p<0.05) elevated the entire time in SAAP patients when compared to patients with MAAP on 5th and 7th day from admission to hospital.
CONCLUSIONS: Patients with SAAP had significantly higher proinflammatory cytokine IL-6 levels and neutrophil counts than patients with MAAP. The results suggest that proliferation and overstimulation of this subset of leukocytes might contribute to the development of the systemic inflammatory response in patients with SAAP.
Józefa Panek; Beata Kuśnierz-Cabala; Mirosław Dolecki; Jonathan Pietron
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Polski przeglad chirurgiczny     Volume:  84     ISSN:  0032-373X     ISO Abbreviation:  Pol Przegl Chir     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-07-05     Completed Date:  2012-11-19     Revised Date:  2014-06-11    
Medline Journal Info:
Nlm Unique ID:  0376426     Medline TA:  Pol Przegl Chir     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  230-7     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Cytokines / blood*
Interleukin-12 Subunit p40 / blood
Interleukin-6 / blood
Interleukin-8 / blood
Leukocyte Count*
Middle Aged
Neutrophils / metabolism*,  pathology
Pancreatitis, Alcoholic / blood,  complications,  metabolism*
Serum / metabolism*
Systemic Inflammatory Response Syndrome / etiology
Young Adult
Reg. No./Substance:
0/Cytokines; 0/Interleukin-12 Subunit p40; 0/Interleukin-6; 0/Interleukin-8

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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