Document Detail

Serum progesterone for the exclusion of early pregnancy in women at risk for recurrent gestational trophoblastic neoplasia.
MedLine Citation:
PMID:  7936514     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the utility of the serum progesterone level for discriminating pregnancy from gestational trophoblastic neoplasia. METHODS: Serum progesterone levels were measured in 61 women with histories of trophoblastic disease who developed a re-elevation in hCG during surveillance and underwent a work-up to differentiate pregnancy from gestational trophoblastic neoplasia. Progesterone levels were analyzed in the context of diagnostic outcome (pregnancy versus gestational trophoblastic neoplasia) to identify optimal threshold levels of progesterone to be used for classifying outcome. RESULTS: Of the 61 women, 37 proved to be pregnant and 24 had gestational trophoblastic neoplasia. Progesterone less than 2.5 ng/mL was predictive of trophoblastic malignancy, with a sensitivity of 83% (20 of 24 subjects were classified correctly as having gestational trophoblastic neoplasia) and a specificity of 95% (35 of 37 patients with progesterone levels at or above 2.5 ng/mL were correctly classified as pregnant). Progesterone of at least 10 ng/mL was associated with viable pregnancy in 97% of the cases. Furthermore, the progesterone level predicted outcome regardless of the serum hCG value. CONCLUSION: The serum progesterone level is useful for discriminating early pregnancy from gestational trophoblastic neoplasia.
G C Rodriguez; C L Hughes; J T Soper; A Berchuck; D L Clarke-Pearson; C B Hammond
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  84     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1994-11-16     Completed Date:  1994-11-16     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  794-7     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina.
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MeSH Terms
Chorionic Gonadotropin / blood
Diagnosis, Differential
Middle Aged
Neoplasm Recurrence, Local / diagnosis*
Pregnancy Tests*
Progesterone / blood*
Retrospective Studies
Risk Factors
Trophoblastic Neoplasms / diagnosis*
Uterine Neoplasms / diagnosis*
Reg. No./Substance:
0/Chorionic Gonadotropin; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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