Document Detail


Serum progesterone and corpus luteum function in pregnant pigtailed monkeys (Macaca nemestrina).
MedLine Citation:
PMID:  7444998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Corpus luteum (CL) function and control during pregnancy and early lactation in the pigtailed macaque was investigated. Peripheral concentrations of progesterone (P) on day 10 of pregnancy were 12.98 +/- 2.21 ng/ml and decreased progressively to 7.96 +/- 1.27 ng/ml by day 21 of pregnancy. The concentration of P increased around day 27 of gestation and reached peak levels of 18.48 +/- 2.45 ng/ml on day 37, thereafter gradually decreasing to a nadir at about midgestation. Ten days before parturition P concentrations increased again (P < 0.05). Concentrations of P decreased from 6.62 +/- 1.48 ng/ml on the day of delivery to 2.16 +/- 0.43 ng/ml on day 2 of lactation and remained low thereafter. Ovariectomy on day 35 did not affect the normal course of gestation or the patterns of P secretion during pregnancy. However, in these ovariectomized animals, in spite of suckling, P was not detectable after parturition. In intact monkeys, serum concentrations of P in the utero-ovarian vein at days 80 and 159 of pregnancy were higher relative to the uterine vein. Incubation studies utilizing 3H-cholesterol as a substrate revealed that the CL were capable of synthesizing P on days 35 and 159 of gestation. Histologically, the CL contained active luteal cells at late pregnancy. Low serum concentrations of chorionic gonadotropin were detected on day 10 of gestation; concentrations of this hormone reached high levels between days 18 and 24 and the titers were nondetectable after day 40 of pregnancy. Luteinizing hormone was present in constant amounts in the circulation during pregnancy and lactation. These data suggest that the CL of pregnancy in the pigtailed monkey is functional or capable of functioning during various stages of pregnancy. However, the fetoplacental unit is the primary source of P during the latter 4.5 months of gestation. As in other primates, a functional CL is not required for maintenance of pregnancy after implantation nor for lactation. Thus, the physiological significance of CL function during pregnancy is unclear.
Authors:
V Chandrashekar; R C Wolf; D J Dierschke; S A Sholl; W E Bridson; J R Clark
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Steroids     Volume:  36     ISSN:  0039-128X     ISO Abbreviation:  Steroids     Publication Date:  1980 Oct 
Date Detail:
Created Date:  1981-02-19     Completed Date:  1981-02-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  483-95     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Castration
Chorionic Gonadotropin / blood
Corpus Luteum / physiology*
Female
Gestational Age
Lactation
Luteinizing Hormone / blood
Macaca / physiology*
Macaca nemestrina / physiology*
Pregnancy
Pregnancy Maintenance
Pregnancy, Animal*
Progesterone / blood*
Grant Support
ID/Acronym/Agency:
RR-00167/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 57-83-0/Progesterone; 9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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