Document Detail

Serum profiles of monocyte chemoattractant protein-1 as a biomarker for patients recovering from myocardial infarction.
MedLine Citation:
PMID:  20140679     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) plays a key role in the pathogenesis of atherosclerosis and has been proposed as a biomarker for patients with cardiovascular disease. METHODS: To assess its clinical usefulness, serum MCP-1 concentrations were measured in patients with ST-elevation myocardial infarction (MI) at admission, immediately after percutaneous coronary intervention (PCI), at 24 h, and after 6 months. RESULTS: We found no differences in MCP-1 concentrations between patients with acute MI, patients with stable coronary artery disease and healthy individuals. Although median MCP-1 concentrations in patients with MI were similar at admission and after 6 months, there were significant differences between individuals in how MCP-1 levels changed with time. As demonstrated by comparing baseline quartiles of MCP-1, the levels of MCP-1 tended to increase in patients with low MCP-1 concentration at admission, and decrease in patients with initially high MCP-1 levels. We found an inverse correlation between MCP-1 concentration at baseline and the time to reperfusion, and detected a significant decrease in MCP-1 concentration immediately after PCI. We also observed lower MCP-1 concentrations over time in patients who developed restenosis within 6 months. However, we did not confirm the association between MCP-1 concentrations at baseline and a number of previously implicated demographic, clinical and laboratory criteria. CONCLUSIONS: Our data demonstrate some new aspects of MCP-1 measurement in patients with MI, but do not corroborate many earlier observations.
Katarzyna Korybalska; Małgorzata Pyda; Stefan Grajek; Magdalena Lanocha; Andrzej Breborowicz; Janusz Witowski
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Publication Detail:
Type:  Journal Article     Date:  2010-02-07
Journal Detail:
Title:  Clinical research in cardiology : official journal of the German Cardiac Society     Volume:  99     ISSN:  1861-0692     ISO Abbreviation:  Clin Res Cardiol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264123     Medline TA:  Clin Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  315-22     Citation Subset:  IM    
Department of Pathophysiology, Poznan University of Medical Sciences, Swiecickiego 6, 60-781, Poznan, Poland.
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MeSH Terms
Biological Markers / blood
Chemokine CCL2 / blood*
Diagnosis, Computer-Assisted / methods*
Middle Aged
Myocardial Infarction / blood*,  diagnosis*
Recovery of Function
Reproducibility of Results
Sensitivity and Specificity
Reg. No./Substance:
0/Biological Markers; 0/Chemokine CCL2

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