Document Detail


Serum pituitary antibodies in normal pregnancy and in patients with postpartum thyroiditis: a nested case-control study.
MedLine Citation:
PMID:  18787047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aim of this study was to evaluate antipituitary antibody (APA) prevalence in a series of patients with postpartum thyroiditis (PPT) during pregnancy and in the postpartum. DESIGN: We conducted a nested case-control study on consecutive PPT and normal pregnant women at the Centre for Endocrine and Diabetes Sciences in Cardiff and at the Department of Endocrinology in Pisa. METHODS: We enrolled 30 women with PPT: 17 were hypothyroid (Hypo), 7 with hyperthyroidism (Hyper) and 6 with a transient hyperthyroidism followed by hypothyroidism (Biphasic). Twenty-one healthy pregnant women served as controls. APA (measured using indirect immunofluorescence), free thyroxine, free triiodothyronine, TSH, antithyroid autoantibodies, and thyroid ultrasound were performed during pregnancy and postpartum. The stored sera have been sent to Pisa, where serum APA, IGF1, and cortisol were measured. RESULTS: APA were found in 8 out of the 30 PPT patients (26.7%) and in one normal pregnancy (4.7%, P=0.063). Three out of the seventeen Hypo with PPT (17.6%), three out of the seven Hyper PPT (42.8%), and two out of the six Biphasic PPT (33.3%) were positive for APA. APA prevalence was not significantly different in the PPT subgroups (P=0.453). With one exception, APA all increased in the postpartum period (87.5%, P<0.016). Basal serum IGF1 and cortisol were in the normal range with the exception of two patients with positive APA who presented low serum IGF1 levels (36 and 45 ng/ml). CONCLUSIONS: APA are frequently present in the postpartum period in patients affected by PPT. Further studies are necessary to evaluate whether APA in PPT patients are associated with pituitary function impairment.
Authors:
Luca Manetti; Arthur B Parkes; Isabella Lupi; Graziano Di Cianni; Fausto Bogazzi; Sonia Albertini; Lisa Linda Morselli; Valentina Raffaelli; Dania Russo; Giuseppe Rossi; Maurizio Gasperi; John H Lazarus; Enio Martino
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-11
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  159     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-05     Completed Date:  2009-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  805-9     Citation Subset:  IM    
Affiliation:
Department of Endocrinology, University of Pisa, Ospedale Cisanello, Via Paradisa 2, 56124 Pisa, Italy. lmanetti@endoc.med.unipi.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Autoantibodies / blood*
Autoimmune Diseases / blood,  enzymology,  epidemiology
Case-Control Studies
Cohort Studies
Female
Humans
Iodide Peroxidase / immunology
Pituitary Gland / immunology*,  metabolism*,  pathology
Postpartum Thyroiditis / epidemiology,  immunology*,  pathology
Pregnancy
Pregnancy Proteins / blood,  immunology
Thyroglobulin / immunology
Young Adult
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Pregnancy Proteins; 9010-34-8/Thyroglobulin; EC 1.11.1.8/Iodide Peroxidase

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