| Serum phospholipid fractions measured by two dimensional thin layer chromatography in normal pregnancy. | |
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MedLine Citation:
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PMID: 2628299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum phospholipid fractions were quantitated by two dimensional thin layer chromatography in 85 apparently normal pregnant women at different gestational period. Fifteen healthy non-pregnant women matched for age served as controls. Normal chromatogram showed eight spots of serum phospholipid viz., phosphatidic acid (PA, 3.9 +/- 0.5%), cardiolipin (C, 7.2 +/- 0.4%), phosphatidylethanolamine (PE, 10.6 +/- 1.1%), phosphatidylglycerol (PG, 3.2 +/- 0.6%), lecithin (L, 34.5 +/- 1.8%), sphingomyelin (S, 31.0 +/- 1.4%), lysolecithin (LL, 8.6 +/- 1.2%) and phosphalidylionositol (PI, 1.0 +/- 0.2%). Serum total phospholipid which increased with gestational age, being lowest at 6 wk (220.2 +/- 4.8 mg/dl) and highest at 38 wk (290.3 +/- 4.5 mg/dl), started declining at term (275.8 +/- 5.8 mg/dl) and returned to levels in normal nonpregnant women (214.1 +/- 4.7 mg/dl) at 4 wk after delivery (217.2 +/- 3.3 mg/dl). PG was absent in both the first and second trimester and first appeared between 31-32 wk, i.e., in the third trimester of pregnancy when the mean per cent of PG was 0.7 +/- 0.4 per cent. During the first trimester when the L/S ratio was less than 1.2 the PI level was low (0.8 +/- 0.2%). Parallel to the increase in the L/S ratio to 2.0, the content of PI increased to 2.6 +/- 0.4 per cent. PG first appeared (0.7 +/- 0.4%) and PI concomitantly decreased (2.1 +/- 0.3%) when the L/S ratio exceeded 2.0 at 31-32 wk. Sequential analysis of maternal serum phospholipid fractions may be used as an additional tool in predicting gestational age of normal growing pregnancy. |
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Authors:
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S K Batabyal; S Chaudhuri; A Ghosh; B Mitra; C S Dawn |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Indian journal of medical research Volume: 90 ISSN: 0971-5916 ISO Abbreviation: Indian J. Med. Res. Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1990-04-23 Completed Date: 1990-04-23 Revised Date: 2013-04-18 |
Medline Journal Info:
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Nlm Unique ID: 0374701 Medline TA: Indian J Med Res Country: INDIA |
Other Details:
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Languages: eng Pagination: 315-9 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chromatography, Thin Layer Female Humans Phospholipids / blood* Pregnancy / blood* |
| Chemical | |
Reg. No./Substance:
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0/Phospholipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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