Document Detail


Serum paraoxonase-3 concentration in HIV-infected patients. Evidence for a protective role against oxidation.
MedLine Citation:
PMID:  22003209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the influence of the HIV infection on serum paraoxonase-3 (PON3) concentration and assessed the relationships with lipoprotein-associated abnormalities, immunological response, and accelerated atherosclerosis. We studied 207 HIV-infected patients and 385 healthy volunteers. Serum PON3 was determined by in-house ELISA, and PON3 distribution in lipoproteins was investigated by fast-performance liquid chromatography (FPLC). Polymorphisms of the PON3 promoter were analyzed by the Iplex Gold MassArray(TM) method. PON3 concentrations were increased (about three times) in HIV-infected patients with respect to controls (P < 0.001) and were inversely correlated with oxidized LDL levels (P = 0.038). Long-term use of nonnucleoside reverse transcriptase inhibitor (NNRTI)-based antiretroviral therapy was associated with a decrease of PON3 concentrations. In a multivariate linear regression analysis, these relationships were still strong when the main confounding covariates were considered. PON3 was mainly found in HDL in HIV-infected patients, but a substantial amount of the protein was detected in LDL particles. This study reports for the first time an important increase in serum PON3 concentrations in HIV-infected patients that is associated with their oxidative status and their treatment with NNRTI. Long-term, prospective studies are needed to confirm the possible influence of this enzyme on the course of this disease and its possible utility as an analytical biomarker.
Authors:
Gerard Aragonès; Anabel García-Heredia; Marta Guardiola; Anna Rull; Raúl Beltrán-Debón; Judit Marsillach; Carlos Alonso-Villaverde; Bharti Mackness; Michael Mackness; Juan Pedro-Botet; Pedro Pardo-Reche; Jorge Joven; Jordi Camps
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-10-14
Journal Detail:
Title:  Journal of lipid research     Volume:  53     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-16     Completed Date:  2012-04-09     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  168-74     Citation Subset:  IM    
Affiliation:
Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aryldialkylphosphatase / blood*,  genetics
Female
HIV Infections / blood,  enzymology*
Humans
Lipoproteins / blood
Lipoproteins, LDL / blood
Male
Middle Aged
Oxidation-Reduction
Chemical
Reg. No./Substance:
0/Lipoproteins; 0/Lipoproteins, LDL; 0/oxidized low density lipoprotein; EC 3.1.8.1/Aryldialkylphosphatase; EC 3.1.8.1/PON3 protein, human
Comments/Corrections

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