Document Detail

Serum ox-LDL Level is Reduced with the Extent of Stenosis in Coronary Arteries.
MedLine Citation:
PMID:  23737315     Owner:  NLM     Status:  In-Data-Review    
Oxidized LDL (ox-LDL) lipoproteins are proposed as important modified particles triggering pro-inflammatory events through receptor-mediated pathways. We evaluated the circulating ox-LDL level on the concept that the chronic immune events may affect ox-LDL clearance as the vessel stenosis develops in coronary arteries. One hundred sixty five subjects underwent coronary angiography and then, subdivided into four subgroups controls (n=85); SVD, 2VD and 3VD (n=80). The serum ox-LDL level and other biochemical parameters were measured using ELISA method and routine laboratory techniques, respectively. The serum ox-LDL level in the control group (4.81±1.41 mU/mg) was significantly higher than patients (4.28±1.73 mU/mg, P<0.05). The ox-LDL/LDL ratio was conversely reduced with the extent of stenosis as compared with the controls (P<0.05). Furthermore, no difference was observed in the ox-LDL/LDL ratio between the 2VD and 3VD patients. We suggested the atherosclerosis process increases the total clearing capacities of the circulating ox-LDL particles.
Mohammad Najafi; Behnam Alipoor
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Publication Detail:
Type:  Journal Article     Date:  2013-05-30
Journal Detail:
Title:  Acta medica Iranica     Volume:  51     ISSN:  1735-9694     ISO Abbreviation:  Acta Med Iran     Publication Date:  2013  
Date Detail:
Created Date:  2013-06-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  14540050R     Medline TA:  Acta Med Iran     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  314-9     Citation Subset:  IM    
Department of Biochemistry, Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
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