| Serum osteoprotegerin is markedly increased and may contribute to decreased blood T cell count in hemodialysis patients. | |
| | |
MedLine Citation:
|
PMID: 23296793 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE: Acquired immunity is impaired in hemodialysis (HD) patients, and decreased T cell number may contribute. Receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) are expressed in cells of the immune system and affect T cell development, homeostasis and proliferation. Serum levels of RANKL and OPG and their relation to blood T cell number were evaluated in HD patients. METHODS: Thirty-four HD patients and 20 healthy controls participated in the study. Serum RANKL and OPG were measured by ELISA and T cell number was assessed by flow cytometry. RESULTS: Median RANKL concentration did not differ between HD patients and healthy volunteers (300.00 pmol/L; range, 3,340.00 vs. 330.00 pmol/L; range, 440.00 pmol/L; p = 0.528). Median OPG was markedly higher in HD patients than in healthy volunteers (13.12 ± 4.71 vs. 4.71 ± 0.93 pmol/L, p < 0.001). The T cell count was significantly lower in HD patients than in healthy controls (1,177.00 ± 567.71 vs. 1,519.80 ± 594.96 cells/mm(3), p = 0.044). In HD patients, blood T cell number was correlated positively with serum RANKL (ρ = 0.462, p = 0.007) and negatively to serum OPG (r = -0.449, p = 0.008). CONCLUSION: Serum OPG concentration is markedly increased in HD patients and may contribute to decreased blood T cell count and impaired acquired immunity that characterizes this population. |
| | |
Authors:
|
Theodoros Eleftheriadis; Efi Yiannaki; Vassilios Liakopoulos; Georgia Antoniadi; Georgios Pissas; Grammati Galaktidou; Ioannis Stefanidis |
Related Documents
:
|
23516323 - Gray matter atrophy distinguishes between parkinson disease motor subtypes. 22957243 - Active epilepsy as indicator of neurocysticercosis in rural northwest india. 6187093 - Surgical treatment of bacterial endocarditis. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-8 |
Journal Detail:
|
Title: International urology and nephrology Volume: - ISSN: 1573-2584 ISO Abbreviation: Int Urol Nephrol Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0262521 Medline TA: Int Urol Nephrol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Nephrology, Medical School, University of Thessaly, Neo Ktirio, Mezourlo Hill, 41110, Larissa, Greece, teleftheriadis@yahoo.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fibroblast growth factor 23: associations with cardiovascular disease and mortality in chronic kidne...
Next Document: GABAergic inputs from direct and indirect striatal projection neurons onto cholinergic interneurons ...