| Serum osmolal gap in patients with idiopathic nephrotic syndrome and severe edema. | |
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MedLine Citation:
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PMID: 17485452 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pseudohyponatremia in idiopathic nephrotic syndrome with severe edema is attributed to hyperlipidemia that results in displacement of a portion of water phase of plasma. Current methods of measurement of serum electrolytes are unaffected by hyperlipidemia. In this report we demonstrate that patients with idiopathic nephrotic syndrome with severe edema and true hyponatremia may have an increased rather than normal osmolal gap. We believe that this could be secondary to non-Na+ and non-K+ osmoles in response to plasma-volume contraction secondary to hypoalbuminemia. This observation has implications for management of severe edema in such patients, because fluid restriction could increase their risk for pre-renal failure. |
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Authors:
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Gaurav Kapur; Rudolph P Valentini; Abubakr A Imam; Amrish Jain; Tej K Mattoo |
Publication Detail:
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Type: Journal Article Date: 2007-05-07 |
Journal Detail:
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Title: Pediatrics Volume: 119 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-04 Completed Date: 2007-07-09 Revised Date: 2007-08-28 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: e1404-7 Citation Subset: AIM; IM |
Affiliation:
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Division of Nephrology and Hypertension, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Child, Preschool Edema / blood*, complications, diagnosis Female Humans Hyponatremia / blood, complications, diagnosis Male Nephrotic Syndrome / blood*, complications, diagnosis Osmolar Concentration Serum / chemistry*, metabolism |
| Comments/Corrections | |
Erratum In:
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Pediatrics. 2007 Aug;120(2):460 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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