Document Detail


Serum non-esterified very long-chain PUFA are associated with markers of endothelial dysfunction.
MedLine Citation:
PMID:  12204798     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to investigate the pattern of serum non-esterified fatty acid (NEFA) fraction in association with atherosclerosis development. We have studied possible relationships between eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (AA) in the NEFA fraction and biochemical markers of endothelial activation or dysfunction. The study population consisted of 152 elderly men with high risk for coronary heart disease. The composition of fasting serum NEFA was analysed by gas-liquid chromatography. Endothelial activation was evaluated using biochemical analyses of some markers of endothelial function. A significant inverse linear association was found between serum non-esterified EPA and DHA, and soluble vascular cell adhesion molecule-1 (sVCAM-1) (P=0.02 and 0.001, respectively). An inverse linear association was found between serum non-esterified AA and sVCAM-1 (P=0.001) and von Willebrand Factor (P=0.005). The significant inverse associations for DHA and AA were independent from the serum content of other NEFAs. Taken together, negative associations were found between sVCAM-1 and the serum levels of non-esterified DHA, EPA and AA. The inverse relation between the levels of sVCAM-1 and very long-chain n-3 fatty acids might indicate an anti-inflammatory effect of the latter.
Authors:
Paula Yli-Jama; Ingebjørg Seljeflot; Haakon E Meyer; Elsa M Hjerkinn; Harald Arnesen; Jan I Pedersen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Atherosclerosis     Volume:  164     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-02     Completed Date:  2003-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  275-81     Citation Subset:  IM    
Affiliation:
Institute for Nutrition Research, University of Oslo, PO Box 1046, Blindern, N-0316, Oslo, Norway. paula.yli-jama@basalmed.uio.no
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MeSH Terms
Descriptor/Qualifier:
Aged
Arteriosclerosis / etiology*,  physiopathology
Biological Markers / analysis
Cohort Studies
Coronary Disease / etiology*,  physiopathology
Eicosanoic Acids / blood,  metabolism
Endothelium, Vascular / metabolism,  physiopathology*
Fatty Acids, Nonesterified / blood*,  metabolism
Fatty Acids, Unsaturated / blood*,  metabolism
Humans
Male
Probability
Sampling Studies
Sensitivity and Specificity
Statistics, Nonparametric
Vascular Cell Adhesion Molecule-1 / blood*,  metabolism
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Eicosanoic Acids; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Unsaturated; 0/Vascular Cell Adhesion Molecule-1

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