Document Detail

Serum neutrophil gelatinase-associated lipocalin as a marker of kidney function in pregnancy - useful or doubtful?
MedLine Citation:
PMID:  22419934     Owner:  NLM     Status:  PubMed-not-MEDLINE    
INTRODUCTION: The aim of the study was to assess whether neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C could reflect kidney function in pregnant healthy women.
MATERIAL AND METHODS: The studies were performed on 130 healthy pregnant women (n = 63, 3(rd) trimester; n = 21, 2(nd) trimester; n = 46, 1(st) trimester) and 30 healthy female volunteers. Serum NGAL, cystatin C, IL-6, and hs-CRP were assayed using commercially available kits.
RESULTS: Serum cystatin C rose steadily during the pregnancy, whereas NGAL rose in the 2(nd) trimester, then decreased in the 3(rd) trimester. In univariate analysis, NGAL correlated with serum cystatin C, number of pregnancies, white blood cell count, total iron-binding capacity (TIBC), ferritin, and IL-6, and tended to correlate with eGFR. In multiple regression analysis the only predictor of serum NGAL was cystatin C.
CONCLUSIONS: Serum NGAL in pregnancy might reflect subclinical inflammation rather than kidney function. It seems that NGAL, similarly to cystatin C, is not useful to monitor renal function in pregnancy.
Jacek S Małyszko; Leszek Rams; Lena Drozdowska-Rams; Jolanta Małyszko
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Publication Detail:
Type:  Journal Article     Date:  2010-10-26
Journal Detail:
Title:  Archives of medical science : AMS     Volume:  6     ISSN:  1896-9151     ISO Abbreviation:  Arch Med Sci     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2012-03-15     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101258257     Medline TA:  Arch Med Sci     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  744-7     Citation Subset:  -    
Department of Nephrology and Transplantology, Medical University, Bialystok, Poland.
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