Document Detail


Serum neutrophil gelatinase-associated lipocalin as a marker of kidney function in pregnancy - useful or doubtful?
MedLine Citation:
PMID:  22419934     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The aim of the study was to assess whether neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C could reflect kidney function in pregnant healthy women.
MATERIAL AND METHODS: The studies were performed on 130 healthy pregnant women (n = 63, 3(rd) trimester; n = 21, 2(nd) trimester; n = 46, 1(st) trimester) and 30 healthy female volunteers. Serum NGAL, cystatin C, IL-6, and hs-CRP were assayed using commercially available kits.
RESULTS: Serum cystatin C rose steadily during the pregnancy, whereas NGAL rose in the 2(nd) trimester, then decreased in the 3(rd) trimester. In univariate analysis, NGAL correlated with serum cystatin C, number of pregnancies, white blood cell count, total iron-binding capacity (TIBC), ferritin, and IL-6, and tended to correlate with eGFR. In multiple regression analysis the only predictor of serum NGAL was cystatin C.
CONCLUSIONS: Serum NGAL in pregnancy might reflect subclinical inflammation rather than kidney function. It seems that NGAL, similarly to cystatin C, is not useful to monitor renal function in pregnancy.
Authors:
Jacek S Małyszko; Leszek Rams; Lena Drozdowska-Rams; Jolanta Małyszko
Related Documents :
3353864 - Long-term changes in medication during pregnancy.
20082584 - Glycemic control and selected pregnancy outcomes in type 1 diabetes women on continuous...
22905304 - Elevated maternal serum α-fetoprotein level in a fetus with beckwith-wiedemann syndrome...
22360844 - First-trimester maternal serum vitamin d and mode of delivery.
8623804 - Peripheral joint laxity increases in pregnancy but does not correlate with serum relaxi...
12076384 - Interventions to help external cephalic version for breech presentation at term.
Publication Detail:
Type:  Journal Article     Date:  2010-10-26
Journal Detail:
Title:  Archives of medical science : AMS     Volume:  6     ISSN:  1896-9151     ISO Abbreviation:  Arch Med Sci     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2012-03-15     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101258257     Medline TA:  Arch Med Sci     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  744-7     Citation Subset:  -    
Affiliation:
Department of Nephrology and Transplantology, Medical University, Bialystok, Poland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Morphogenetic aspects of the septomarginal trabecula in the human heart.
Next Document:  The use of whey protein concentrate in management of chronic hepatitis C virus - a pilot study.