| Serum n3 polyunsaturated fatty acids are depleted in Crohn's disease. | |
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MedLine Citation:
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PMID: 9201073 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine fatty acid patterns in Crohn's disease, we measured various serum fatty acids by gas chromatography in 20 patients with the disease and compared them with those in 18 healthy controls. All the patients had been free from any nutritional supplementation during preceding six months or had no history of intestinal resection. Eight of the patients were affected in the small bowel only, three in the large bowel only, and the remaining nine in both the small and large bowel. Both serum concentrations and percentages of C20:4n6, C20:5n3, C22:0, C22:6n3, total n3 polyunsaturated fatty acids, and total polyunsaturated fatty acids were lower in the patients than in the controls. Both essential fatty acids (C18:2n6, C18:3n3) and C20:3n9 levels were not different between the two groups. Among nine fatty acids that correlated with the Crohn's disease activity index, C20:5n3 and total n3 polyunsaturated fatty acids showed the most significant negative correlations. These findings suggest that essential fatty acid deficiency rarely occurs in Crohn's disease and also that n3 polyunsaturated fatty acids may be relevant to the activity of the disease. |
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Authors:
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F Kuroki; M Iida; T Matsumoto; K Aoyagi; K Kanamoto; M Fujishima |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 42 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-07-16 Completed Date: 1997-07-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1137-41 Citation Subset: AIM; IM |
Affiliation:
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Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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8,11,14-Eicosatrienoic Acid
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analogs & derivatives,
blood,
metabolism Adult Chromatography, Gas Crohn Disease / blood*, metabolism Fatty Acids, Essential / blood, metabolism Fatty Acids, Omega-3 / blood*, metabolism Fatty Acids, Unsaturated / blood, metabolism Female Humans Male Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Essential; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Unsaturated; 2751-14-6/mead acid; 7324-41-6/8,11,14-Eicosatrienoic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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