Document Detail

Serum n-6 fatty acids and lipoprotein subclasses in middle-aged men: the population-based cross-sectional ERA-JUMP study.
MedLine Citation:
PMID:  20357040     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The associations of serum omega-6 (n-6) fatty acids with lipoprotein subclasses at the population level are uncertain.
OBJECTIVE: We aimed to examine associations between major n-6 fatty acids [ie, linoleic acid (LA, 18:2n-6) and arachidonic acid (AA, 20:4n-6)] and the lipoprotein subclasses VLDL, LDL, and HDL.
DESIGN: We conducted a cross-sectional study in 1098 participants using population-based data from US white, Japanese American, Japanese, and Korean men aged 40-49 y. Serum fatty acids were analyzed by capillary gas-liquid chromatography. Lipoprotein subclasses were measured by nuclear magnetic resonance spectroscopy. Multiple linear regression models as a function of each fatty acid were used after adjustment for age, population, body mass index, pack-years of smoking, alcohol consumption, diabetes, hypertension, and omega-3 (n-3) and trans fatty acids.
RESULTS: Serum LA was inversely associated with large VLDL (beta = -0.62, P < 0.001), total LDL (beta = -22.08, P < 0.001), and small LDL (beta = -31.89, P < 0.001) particle concentrations and VLDL size (beta = -0.72, P < 0.001). Serum LA was positively associated with large HDL particle concentration (beta = 0.21, P < 0.001) and HDL size (beta = 0.03, P < 0.001). The patterns of association of AA with large VLDL and large HDL particle concentrations were comparable with those of LA.
CONCLUSIONS: At the population level, higher serum concentrations of LA were significantly associated with lower concentrations of total LDL particles. Higher serum concentrations of LA and AA were significantly associated with a lower concentration of large VLDL particles and a higher concentration of large HDL particles. These associations were consistent across the population groups. This trial was registered at as NCT00069797.
Jina Choo; Hirotsugu Ueshima; J David Curb; Chol Shin; Rhobert W Evans; Aiman El-Saed; Takashi Kadowaki; Tomonori Okamura; Katsumi Nakata; Teruo Otake; Katsuyuki Miura; Robert D Abbott; Kim Sutton-Tyrrell; Daniel Edmundowicz; Lewis H Kuller; Akira Sekikawa;
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-03-31
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  91     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-05-28     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1195-203     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Body Mass Index
Cholesterol / blood
Cholesterol, LDL / blood
Cross-Sectional Studies
Diabetes Mellitus, Type 2 / epidemiology
Fatty Acids / blood
Fatty Acids, Omega-6 / blood*
Hypertension / epidemiology
Lipoproteins / blood*
Lipoproteins, HDL / blood
Lipoproteins, LDL / blood
Lipoproteins, VLDL / blood
Magnetic Resonance Spectroscopy
Middle Aged
Patient Selection
Regression Analysis
Smoking / physiopathology
Grant Support
R01 HL068200/HL/NHLBI NIH HHS; R01 HL068200-01A1/HL/NHLBI NIH HHS; R01 HL068200-02/HL/NHLBI NIH HHS; R01 HL068200-03/HL/NHLBI NIH HHS; R01 HL068200-04/HL/NHLBI NIH HHS; R01 HL68200/HL/NHLBI NIH HHS; R01-HL071561/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Cholesterol, LDL; 0/Fatty Acids; 0/Fatty Acids, Omega-6; 0/Lipoproteins; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Lipoproteins, VLDL; 97C5T2UQ7J/Cholesterol

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