| Serum n-6 fatty acids and lipoprotein subclasses in middle-aged men: the population-based cross-sectional ERA-JUMP study. | |
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MedLine Citation:
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PMID: 20357040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The associations of serum omega-6 (n-6) fatty acids with lipoprotein subclasses at the population level are uncertain. OBJECTIVE: We aimed to examine associations between major n-6 fatty acids [ie, linoleic acid (LA, 18:2n-6) and arachidonic acid (AA, 20:4n-6)] and the lipoprotein subclasses VLDL, LDL, and HDL. DESIGN: We conducted a cross-sectional study in 1098 participants using population-based data from US white, Japanese American, Japanese, and Korean men aged 40-49 y. Serum fatty acids were analyzed by capillary gas-liquid chromatography. Lipoprotein subclasses were measured by nuclear magnetic resonance spectroscopy. Multiple linear regression models as a function of each fatty acid were used after adjustment for age, population, body mass index, pack-years of smoking, alcohol consumption, diabetes, hypertension, and omega-3 (n-3) and trans fatty acids. RESULTS: Serum LA was inversely associated with large VLDL (beta = -0.62, P < 0.001), total LDL (beta = -22.08, P < 0.001), and small LDL (beta = -31.89, P < 0.001) particle concentrations and VLDL size (beta = -0.72, P < 0.001). Serum LA was positively associated with large HDL particle concentration (beta = 0.21, P < 0.001) and HDL size (beta = 0.03, P < 0.001). The patterns of association of AA with large VLDL and large HDL particle concentrations were comparable with those of LA. CONCLUSIONS: At the population level, higher serum concentrations of LA were significantly associated with lower concentrations of total LDL particles. Higher serum concentrations of LA and AA were significantly associated with a lower concentration of large VLDL particles and a higher concentration of large HDL particles. These associations were consistent across the population groups. This trial was registered at clinicaltrials.gov as NCT00069797. |
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Authors:
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Jina Choo; Hirotsugu Ueshima; J David Curb; Chol Shin; Rhobert W Evans; Aiman El-Saed; Takashi Kadowaki; Tomonori Okamura; Katsumi Nakata; Teruo Otake; Katsuyuki Miura; Robert D Abbott; Kim Sutton-Tyrrell; Daniel Edmundowicz; Lewis H Kuller; Akira Sekikawa; |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-03-31 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 91 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-05-28 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1195-203 Citation Subset: AIM; IM |
Affiliation:
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College of Nursing, Korea University, Seoul, South Korea. jinachoo@gmail.com |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00069797 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Body Mass Index Cholesterol / blood Cholesterol, LDL / blood Cross-Sectional Studies Diabetes Mellitus, Type 2 / epidemiology Fatty Acids / blood Fatty Acids, Omega-6 / blood* Humans Hypertension / epidemiology Lipoproteins / blood* Lipoproteins, HDL / blood Lipoproteins, LDL / blood Lipoproteins, VLDL / blood Magnetic Resonance Spectroscopy Male Middle Aged Patient Selection Regression Analysis Smoking / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL068200-01A1/HL/NHLBI NIH HHS; R01 HL068200-02/HL/NHLBI NIH HHS; R01 HL068200-03/HL/NHLBI NIH HHS; R01 HL068200-04/HL/NHLBI NIH HHS; R01 HL68200/HL/NHLBI NIH HHS; R01-HL071561/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; 0/Fatty Acids; 0/Fatty Acids, Omega-6; 0/Lipoproteins; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Lipoproteins, VLDL; 57-88-5/Cholesterol |
| Comments/Corrections | |
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