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Serum myeloperoxidase activity and oxidative stress in patients with acute brucellosis.
MedLine Citation:
PMID:  22465269     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: The role of infection in the pathogenesis of atherosclerosis has been increasingly discussed. Previous studies have suggested that increased myeloperoxidase activity plays an important role in the pathogenesis of atherosclerosis. The aim of this study was to investigate the serum myeloperoxidase activity and catalase activity along with lipid hydroperoxide (LOOH) levels in patients with acute brucellosis. DESIGN AND METHODS: Thirty-two patients with brucellosis and 33 healthy controls were enrolled. Serum myeloperoxidase activity, catalase activity and LOOH levels were determined. RESULTS: Serum myeloperoxidase activity and LOOH levels were significantly higher in patients with brucellosis than controls (p<0.05, p<0.001), while catalase activity were significantly lower (p<0.001). LOOH levels were found to be significantly positively correlated with MPO activity (r=0.297, p=0.016) in patients. CONCLUSIONS: These results indicate that increased myeloperoxidase activity and decreased catalase activity is associated with increased oxidative stress, which may have a role in atherosclerotic processes in brucellosis patients.
Authors:
Mehmet Aslan; Mehmet Resat Ceylan; Mustafa Kasım Karahocagil; Aytekin Cıkman; Mahmut Sunnetcioglu; Mehmet Emin Kucukoglu; Abdullah Taskın
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-19
Journal Detail:
Title:  Clinical biochemistry     Volume:  -     ISSN:  1873-2933     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-4-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Affiliation:
Yuzuncu Yıl University, Medical Faculty, Department of Internal Medicine, Van, Turkey.
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