| Serum myeloperoxidase activity and oxidative stress in patients with acute brucellosis. | |
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MedLine Citation:
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PMID: 22465269 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: The role of infection in the pathogenesis of atherosclerosis has been increasingly discussed. Previous studies have suggested that increased myeloperoxidase activity plays an important role in the pathogenesis of atherosclerosis. The aim of this study was to investigate the serum myeloperoxidase activity and catalase activity along with lipid hydroperoxide (LOOH) levels in patients with acute brucellosis. DESIGN AND METHODS: Thirty-two patients with brucellosis and 33 healthy controls were enrolled. Serum myeloperoxidase activity, catalase activity and LOOH levels were determined. RESULTS: Serum myeloperoxidase activity and LOOH levels were significantly higher in patients with brucellosis than controls (p<0.05, p<0.001), while catalase activity were significantly lower (p<0.001). LOOH levels were found to be significantly positively correlated with MPO activity (r=0.297, p=0.016) in patients. CONCLUSIONS: These results indicate that increased myeloperoxidase activity and decreased catalase activity is associated with increased oxidative stress, which may have a role in atherosclerotic processes in brucellosis patients. |
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Authors:
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Mehmet Aslan; Mehmet Resat Ceylan; Mustafa Kasım Karahocagil; Aytekin Cıkman; Mahmut Sunnetcioglu; Mehmet Emin Kucukoglu; Abdullah Taskın |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-19 |
Journal Detail:
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Title: Clinical biochemistry Volume: - ISSN: 1873-2933 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-4-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
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Yuzuncu Yıl University, Medical Faculty, Department of Internal Medicine, Van, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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