Document Detail


Serum-myelin-basic-protein assay in diagnosis and prognosis of patients with head injury.
MedLine Citation:
PMID:  87549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum levels of myelin basic protein (M.B.P.), a nervous-system-specific protein, were measured in 157 patients after head injury and related both to the type of brain damage and to the clinical outcome assessed three months after injury. Mean concentrations of M.B.P. in patients with severe intracerebral damage, with or without associated extracerebral haematoma, were significantly raised at the time of admission and remained high for two weeks after injury. In patients with extracerebral haematoma not associated with severe intracerebral damage mean M.B.P. values rose four to six days after injury and were significantly raised only in patients with poor eventual outcome. Mean serum-M.B.P. concentrations in patients with a good outcome after injury were similar to those in controls. In patients with a poor outcome the mean M.B.P. levels between two and six days after injury were significantly higher than in those with a good outcome. The assay of serum-M.B.P. may be valuable in assessment of severity of brain damage in patients after head injury and in prediction of outcome.
Authors:
D G Thomas; J W Palfreyman; J G Ratcliffe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1978 Jan 
Date Detail:
Created Date:  1979-09-01     Completed Date:  1979-09-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  113-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Blood-Brain Barrier
Brain Diseases / blood
Brain Injuries / blood*
Brain Neoplasms / blood
Cerebrovascular Disorders / blood
Craniocerebral Trauma / blood*
Hematoma / blood
Humans
Myelin Basic Proteins / blood*
Prognosis
Chemical
Reg. No./Substance:
0/Myelin Basic Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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