| Serum microRNA expression in pregnancies with preeclampsia. | |
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MedLine Citation:
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PMID: 22095477 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Preeclampsia continues to be a mortal disease of pregnant women throughout the world. Recently, geneticists, allied with obstetricians, have opened new frontiers. MicroRNAs (miRNAs) are members of a class of small, noncoding RNA molecules. They are critical posttranscriptional regulators of gene expression. We extracted circulating miRNA from maternal plasma and quantified mir-152 and mir-210. We found up-regulated miR-210 levels as well as down-regulated mir-152 levels in preeclampsia patients.We propose that detection of increased mir-210 levels in maternal serum could be used to improve prediction methods for noninvasive prenatal diagnosis of preeclampsia. |
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Authors:
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T Gunel; Y G Zeybek; P Akçakaya; I Kalelioğlu; A Benian; H Ermis; K Aydınlı |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-8 |
Journal Detail:
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Title: Genetics and molecular research : GMR Volume: 10 ISSN: 1676-5680 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101169387 Medline TA: Genet Mol Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Molecular Biology and Genetics, Faculty of Science, Istanbul University, Vezneciler, Istanbul, Turkey gunel@istanbul.edu.tr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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