Document Detail

Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome.
MedLine Citation:
PMID:  4039876     Owner:  NLM     Status:  MEDLINE    
Maximum nocturnal serum melatonin level (MTmax) in relation to some clinical variables was studied in 32 patients with a major depressive episode and in 33 healthy subjects with reference to the outcome of the dexamethasone suppression test (DST). Significant regressions were found between MTmax levels and clinical rating scores in CPRS, interpreted as retardation symptoms. Four healthy subjects with disposition for dysthymic reactions had subnormal MTmax levels, which differed from MTmax levels in subjects without such disposition. Patients but not the healthy subjects, who reported parental loss before 17 years of age, had subnormal MTmax levels and differed from patients with no reported parental loss. Patients with no reported suicidal behaviour in clinical history had significantly lower MTmax levels than patients with reported suicide attempts. No relations were found between low MTmax levels and diagnoses, duration of illness, reported inheritance for depressive illness or sleep disturbances. A hypothetical low melatonin syndrome in depression is proposed: low nocturnal melatonin, abnormal dexamethasone suppression test, disturbed 24-h rhythm of cortisol, less pronounced daily and annual cyclic variation in depressive symptomatology.
J Beck-Friis; B F Kjellman; B Aperia; F Undén; D von Rosen; J G Ljunggren; L Wetterberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta psychiatrica Scandinavica     Volume:  71     ISSN:  0001-690X     ISO Abbreviation:  Acta Psychiatr Scand     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-06-28     Completed Date:  1985-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370364     Medline TA:  Acta Psychiatr Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  319-30     Citation Subset:  IM    
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MeSH Terms
Circadian Rhythm
Depressive Disorder / blood*,  genetics
Dexamethasone / diagnostic use
Hydrocortisone / blood
Melatonin / blood*
Middle Aged
Sleep Initiation and Maintenance Disorders / blood
Suicide, Attempted
Reg. No./Substance:
50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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