Document Detail

Serum matrix metalloproteinase-3 as a novel marker for risk stratification of patients with nonischemic dilated cardiomyopathy.
MedLine Citation:
PMID:  17996824     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Selective induction of myocardial matrix metalloproteinases (MMPs) has been reported to occur in human nonischemic dilated cardiomyopathy (DCM). We aimed to evaluate the utility of serum MMPs for risk stratification of patients with DCM. METHODS AND RESULTS: We measured serum levels of MMP-2, MMP-3, and MMP-9 using enzyme-linked immunosorbent assay in 71 patients with mild to moderate DCM (left ventricular ejection fraction = 28.3 +/- 11.5%). The primary end point was the composite incidence of cardiac death and hospitalizations for worsening heart failure. During the follow-up period (mean, 28 +/- 16 months), 19 patients had major cardiac events with sudden cardiac death in 6 cases and hospitalizations for worsening heart failure in 13 cases. Multivariate analysis revealed that MMP-3 and B-type natriuretic peptide were significant independent predictors of cardiac events in patients with DCM (hazard ratio 1.41, P = .012; hazard ratio 2.72, P = .048, respectively). According to the Kaplan-Meier analyses of cumulative cardiac event-free rates of the two groups that were based on the median levels of MMPs, the differences in the cardiac event-free curves were significant only for MMP-3 (P = .009). Moreover, patients with elevations of both MMP-3 and B-type natriuretic peptide were found to have the poorest prognosis. CONCLUSION: Our results may address the utility of serum MMP-3 for risk stratification of patients with DCM.
Tomoaki Ohtsuka; Kazuhisa Nishimura; Akira Kurata; Akiyoshi Ogimoto; Hideki Okayama; Jitsuo Higaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  13     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-12     Completed Date:  2008-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  752-8     Citation Subset:  IM    
Division of Cardiology, Ehime University Graduate School of Medicine, Shitsukawa, Tohon, Ehime, Japan.
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MeSH Terms
Biological Markers
Cardiomyopathy, Dilated / blood*,  metabolism,  physiopathology
Case-Control Studies
Disease Progression
Health Status Indicators
Matrix Metalloproteinase 2 / blood
Matrix Metalloproteinase 3 / blood*
Matrix Metalloproteinase 9 / blood
Middle Aged
Myocardium / metabolism
Natriuretic Peptide, Brain / blood
Prospective Studies
Risk Assessment
Severity of Illness Index
Stroke Volume
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain; EC Metalloproteinase 3; EC Metalloproteinase 2; EC Metalloproteinase 9

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