Document Detail


Serum matrix metalloproteinase-2 and increased oxidative stress are associated with carotid atherosclerosis in hemodialyzed patients.
MedLine Citation:
PMID:  16510149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Matrix metalloproteinases (MMPs)/their inhibitors (TIMPs) system and elevated oxidative stress (SOX) have been implicated as important factors in atherosclerosis and vascular remodeling. The aim of the present study was to investigate whether MMPs/TIMPs system is associated with SOX in hemodialyzed (HD) patients. We compared the serum levels of metalloproteinases and their inhibitors, markers of SOX, inflammation and atherosclerosis between HD patients (n=40) with and without cardiovascular disease (CVD) and controls (n=20). Cu/Zn superoxide dismutase (Cu/Zn SOD) were elevated (all p<0.001), whereas total lipid peroxide levels were similar in HD patients and controls. The autoantibodies against oxidized LDL (OxLDL-Ab) levels were increased only in patients with CVD (p<0.05). Intima media thickness (IMT) in both CVD and in patients without CVD significantly exceeded those in the control (p<0.001 and p<0.01, respectively). Serum pre-HD values of MMP-2, TIMP-1 and TIMP-2 were significantly increased in HD patients, especially in the CVD group (all p<0.001), and they were associated with those of Cu/Zn SOD, IMT and CVD prevalence. Multiple regression analysis showed that MMP-2, Cu/Zn SOD levels and age independently and significantly predicted elevated IMT in HD patients. Our results suggest the association between SOX and the MMPs/TIMPs system in HD patients, which could represent one of the mechanisms involved in the progression of atherosclerosis in this population.
Authors:
Krystyna Pawlak; Dariusz Pawlak; Michal Mysliwiec
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Publication Detail:
Type:  Journal Article     Date:  2006-02-28
Journal Detail:
Title:  Atherosclerosis     Volume:  190     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-18     Completed Date:  2007-03-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  IM    
Affiliation:
Department of Nephrology and Clinical Transplantation, Medical University, 14 Zurawia St, 15-540 Białystok, Poland. krystynapawlak@poczta.onet.pl
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MeSH Terms
Descriptor/Qualifier:
Aged
C-Reactive Protein / metabolism
Carotid Arteries / ultrasonography
Carotid Artery Diseases / epidemiology,  metabolism*,  ultrasonography
Female
Humans
Kidney Failure, Chronic / epidemiology,  metabolism*,  therapy
Male
Matrix Metalloproteinase 2 / blood*
Matrix Metalloproteinase 9 / blood
Middle Aged
Oxidative Stress*
Prevalence
Renal Dialysis*
Tissue Inhibitor of Metalloproteinase-1 / blood
Tissue Inhibitor of Metalloproteinase-2 / blood
Tunica Intima / ultrasonography
Tunica Media / ultrasonography
Chemical
Reg. No./Substance:
0/Tissue Inhibitor of Metalloproteinase-1; 127497-59-0/Tissue Inhibitor of Metalloproteinase-2; 9007-41-4/C-Reactive Protein; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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